Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression
- Author
- HOEFLICH, Klaus P1 ; HERTER, Sylvia1 ; STERN, Howard4 ; CHOO, Edna5 ; MURRAY, Lesley1 5 ; FRIEDMAN, Lori S1 ; BELVIN, Marcia1 ; TIEN, Janet1 ; WONG, Leo1 ; BERRY, Leanne1 ; CHAN, Jocelyn1 ; O'BRIEN, Carol2 ; MODRUSAN, Zora3 ; SESHAGIRI, Somasekar3 ; LACKNER, Mark2
[1] Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States
[2] Department of Molecular Diagnostics, Genentech, Inc., South San Francisco, California, United States
[3] Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States
[4] Department of Pathology, Genentech, Inc., South San Francisco, California, United States
[5] Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, United States - Source
Cancer research (Chicago, Ill.). 2009, Vol 69, Num 7, pp 3042-3051, 10 p ; ref : 26 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Efficacité traitement Extracellulaire Facteur prédictif Génétique Inhibiteur Kinase Mitogen-activated protein kinase Mutation Transduction signal Gène raf Enzyme Transferases
- Keyword (en)
- Antineoplastic agent Treatment efficiency Extracellular Predictive factor Genetics Inhibitor Kinase Mitogen-activated protein kinase Mutation Signal transduction Enzyme Transferases
- Keyword (es)
- Anticanceroso Eficacia tratamiento Extracelular Factor predictivo Genética Inhibidor Kinase Mitogen-activated protein kinase Mutación Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Discipline
- Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21678491
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/0008-5472.CAN-08-3563 
https://dx.doi.org/10.1158/0008-5472.CAN-08-3563
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