Substrate Specificity, Inhibitors and Regulation of Human Cytochrome P450 2D6 and Implications in Drug Development
- Author
- ZHOU, Shu-Feng1 2 ; LIU, Jun-Ping3 ; LAI, Xin-Sheng4
[1] Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Victoria 3083, Australia
[2] RMIT Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3083, Australia
[3] Department of Immunology, Central and Eastern Clinical School, Monash University, Prahran, Victoria 3181, Australia
[4] College of Acupuncture and Massage, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510407, China - Source
Current medicinal chemistry. 2009, Vol 16, Num 21, pp 2661-2805, 145 p ; ref : 1199 ref
- ISSN
- 0929-8673
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Bentham, Oak Park, IL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- CYP2D6 drug development hepatocyte nuclear factor-4α inhibitor regulation structure substrate
- Keyword (fr)
- Cytochrome P450 Drug-metabolizing enzyme Homme Hépatocyte Inhibiteur Isozyme Médicament Métabolisme Recherche et développement Régulation Spécificité substrat Substrat Unspecific monooxygenase Cytochrome CYP2D6 Enzyme Oxidoreductases
- Keyword (en)
- Cytochrome P450 Drug-metabolizing enzyme Human Hepatocyte Inhibitor Isozyme Drug Metabolism Research and development Regulation(control) Substrate specificity Substrate Unspecific monooxygenase Enzyme Oxidoreductases
- Keyword (es)
- Citocromo P450 Drug-metabolizing enzyme Hombre Hepatocito Inhibidor Isozima Medicamento Metabolismo Investigación desarrollo Regulación Especificidad sustrato Substrato Unspecific monooxygenase Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A05 Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21780967
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2174/092986709788681985 
https://dx.doi.org/10.2174/092986709788681985
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