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Push-pull benzothiazole derivatives as probes for detecting β-amyloid plaques in Alzheimer's brains

Author
ONO, Masahiro1 ; HAYASHI, Shun1 ; KIMURA, Hiroyuki1 ; KAWASHIMA, Hidekazu2 ; NAKAYAMA, Morio3 ; SAJI, Hideo1
[1] Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
[2] Graduate School of Medicine, Kyoto University, Shogoin Kawahara-cho, Kyoto 606-8507, Japan
[3] Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
Source

Bioorganic & medicinal chemistry. 2009, Vol 17, Num 19, pp 7002-7007, 6 p ; ref : 21 ref

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
Alzheimer's disease Imaging Push-pull dye β-Amyloid
Keyword (fr)
Animal Démence d'Alzheimer Dérivé du benzothiazole Fixation biologique Formation image In vitro In vivo Interaction moléculaire Protéine amyloïde β Souris Spectrométrie fluorescence Synthèse chimique Système nerveux central Ethylène-1,1-dicarbonitrile(2-[4-(2-[6-diméthylaminobenzothiazol-2-yl]vinyl)phényl]) Ethylène-1,1-dicarbonitrile(2-[6-diméthylaminobenzothiazol-2-yl]) Malononitrile dérivé Maladie dégénérative Mammalia Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Rodentia Vertebrata
Keyword (en)
Animal Alzheimer disease Benzothiazole derivatives Biological fixation Imaging In vitro In vivo Molecular interaction β Amyloid protein Mouse Fluorescence spectrometry Chemical synthesis Central nervous system Degenerative disease Mammalia Cerebral disorder Central nervous system disease Nervous system diseases Rodentia Vertebrata
Keyword (es)
Animal Demencia Alzheimer Benzotiazol derivado Fijación biológica Formación imagen In vitro In vivo Interacción molecular Proteína amiloide β Ratón Espectrometría fluorescencia Síntesis química Sistema nervioso central Enfermedad degenerativa Mammalia Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B24 Investigative techniques, diagnostic techniques (general aspects) / 002B24O Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques / 002B24O14 Miscellaneous. Technology

Francis
770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…

Discipline
Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology Scanning and diagnostic techniques
Origin
Inist-CNRS
Database
FRANCIS ; PASCAL
INIST identifier
21960788

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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