Amiodarone and its putative metabolites fail to activate wild type hTAAR1
- Author
- LEWIN, Anita H1 ; NAVARRO, Hernan A1 ; GILMOUR, Brian P1
[1] Center for Organic and Medicinal Chemistry, RTI International, PO Box 12194, Research Triangle Park, NC 27709, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 20, pp 5913-5914, 2 p ; ref : 17 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Amiodarone G protein-coupled receptors Human trace amine-associated receptor 1 hTAAR1
- Keyword (fr)
- Affinité Agoniste Aminoéther Amiodarone Antiangoreux Antiarythmique Composé aromatique Composé bicyclique Cétone Dérivé du benzofurane Dérivé du benzène Homme Hétérocycle oxygène In vitro Mécanisme action Métabolite Relation structure activité Récepteur couplé protéine G Récepteur orphelin Vasodilatateur coronarien Récepteur TAAR Iode Composé organique
- Keyword (en)
- Affinity Agonist Aminoether Amiodarone Antianginal agent Antiarrhythmic agent Aromatic compound Bicyclic compound Ketone Benzofuran derivatives Benzene derivatives Human Oxygen heterocycle In vitro Mechanism of action Metabolite Structure activity relation G protein coupled receptor Orphan receptor Coronary vasodilator agent Trace amine associated receptor Iodine Organic compounds
- Keyword (es)
- Afinidad Agonista Aminoeter Amiodarona Antianginoso Antiarrítmico Compuesto aromático Compuesto bicíclico Cetona Benceno derivado Hombre Heterociclo oxígeno In vitro Mecanismo acción Metabolito Relación estructura actividad Receptor acoplado proteína G Receptor huérfano Vasodilatator coronario Iodo Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F02 Antiarythmic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F03 Antianginal agents. Coronary vasodilator agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22011366
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.08.058 
https://dx.doi.org/10.1016/j.bmcl.2009.08.058
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