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Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

Author
BENDER, Gregor1 ; GOSSET, James2 ; FLORIAN, Jeff3 ; TAN, Keith2 ; FIELD, Mark2 ; MARSHALL, Scott2 ; DEJONGH, Joost4 ; BIES, Robert3 ; DANHOF, Meindert1 4
[1] Leiden-Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, Leiden, Netherlands
[2] Pfizer, Global Research & Development, Sandwich, United Kingdom
[3] University of Pittsburgh, Pennsylvania, United States
[4] LAP&P Consultants BV, Leiden, Netherlands
Source

Pharmaceutical research. 2009, Vol 26, Num 10, pp 2259-2269, 11 p ; ref : 50 ref

CODEN
PHREEB
ISSN
0724-8741
Scientific domain
Pharmacology drugs
Publisher
Springer, New York, NY
Publication country
United States
Document type
Article
Language
English
Author keyword
neuropathic pain optimal sampling synergistic interaction trial simulation
Keyword (fr)
Analgésique Animal Anticonvulsivant Conception Douleur neuropathique Echantillonnage Essai préclinique Interaction Névralgie Pharmacocinétique de la population Prégabaline Prélèvement Rat Sildénafil Simulation Technologie pharmaceutique Vasodilatateur 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Hydrolases Inhibiteur de la phosphodiesterase Inhibiteur de la phosphodiestérase 5 Inhibiteur enzyme Mammalia Pathologie du système nerveux Phosphoric diester hydrolases Rodentia Trouble neurologique Vertebrata
Keyword (en)
Analgesic Animal Anticonvulsant Design Neuropathic pain Sampling Preclinical trial Interaction Neuralgia Population pharmacokinetics Pregabalin Samplings Rat Sildenafil Simulation Pharmaceutical technology Vasodilator agent 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Hydrolases Phosphodiesterase inhibitor Phosphodiesterase 5 inhibitor Enzyme inhibitor Mammalia Nervous system diseases Phosphoric diester hydrolases Rodentia Neurological disorder Vertebrata
Keyword (es)
Analgésico Animal Anticonvulsivante Diseño Dolor neuropática Muestreo Ensayo preclínico Interacción Neuralgia Farmacocinética población Pregabalina Toma de muestra Rata Sildenafilo Simulación Tecnología farmacéutica Vasodilatador 3',5'-Cyclic-GMP phosphodiesterase Enzima Esterases Hydrolases Inhibidor phosphodiesterase Inhibidor fosfodiesterasa 5 Inhibidor enzima Mammalia Sistema nervioso patología Phosphoric diester hydrolases Rodentia Trastorno neurológico Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22036850

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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