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2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp

Author
PACINI, Barbara1 ; AVOLIO, Salvatore1 ; ERCOLANI, Caterina1 ; KOCH, Uwe1 ; MIGLIACCIO, Giovanni1 ; NARJES, Frank1 ; PACINI, Laura1 ; TOMEI, Licia1 ; HARPER, Steven1
[1] IRBM, Merck Research Laboratories Rome, Via Pontina km 30,600, 00040 Pomezia, Rome, Italy
Source

Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 21, pp 6245-6249, 5 p ; ref : 19 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Keyword (fr)
Acide carboxylique Antiviral Complexe enzyme inhibiteur Cycle 5 chaînons Cycle 6 chaînons Dérivé du naphtalène Dérivé du thiophène Hétérocycle azote Hétérocycle soufre In vitro Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation RNA-directed RNA polymerase Relation structure activité Sulfonylurées Synthèse chimique Virus hépatite C NS5B polymerase Pyrimidine-4-carboxylique(5,6-dihydroxy-2-[4-(3-[naphtalène-1-sulfonyl]uréido)-3-thiényl]) Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Keyword (en)
Carboxylic acid Antiviral Inhibitor enzyme complex Five membered ring Six membered ring Naphthalene derivatives Thiophene derivatives Nitrogen heterocycle Sulfur heterocycle In vitro Enzyme inhibitor Binding mode Molecular model Modeling RNA-directed RNA polymerase Structure activity relation Sulfonylureas Chemical synthesis Hepatitis C virus Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Keyword (es)
Acido carboxílico Antiviral Complejo enzima inhibidor Ciclo 5 eslabones Ciclo 6 eslabones Naftaleno derivado Tiofeno derivado Heterociclo nitrógeno Heterociclo azufre In vitro Inhibidor enzima Modo de enlace Modelo molecular Modelización RNA-directed RNA polymerase Relación estructura actividad Sulfonilureas Síntesis química Hepatitis C virus Enzima Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22052704

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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