Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom
- Author
- CAMPOS, Vinícius R1 ; ABREU, Paula A2 ; CARVALHO, Carla2 ; SANCHEZ, Eládio F4 ; FULY, André L2 ; CUNHA, Anna C1 ; CASTRO, Helena C2 ; RODRIGUES, Carlos R3 ; JORDAO, Alessandro K1 ; FERREIRA, Vitor F1 ; DE SOUZA, Maria C. B. V1 ; SANTOS, Fernanda Da C1 ; MOURA, Laura A2 ; DOMINGOS, Thaisa S2
[1] Universidade Federal Fluminense, Departamento de Quimica Orgânica, Programa de Pós-Graduaçâo em Química, Outeiro de São João Batista, s/n°, Niterói 24020-141, Rio de Janeiro, Brazil
[2] Departamento de Biologia Celular e Molecular, Instituto de Biologia, Outeiro de São João Baptista, 24020-141 Universidade Federal Fluminense, Niterói, RJ, Brazil
[3] Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, CEP 21941-590, RJ, Brazil
[4] Fundação Ezequiel Dias, Centro de Pesquisa e Desenvolvimento, Belo Horizonte, MG, Brazil - Source
Bioorganic & medicinal chemistry. 2009, Vol 17, Num 21, pp 7429-7434, 6 p ; ref : 35 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Biological activities Diazo compounds Lachesis muta Snake venoms Triazoles
- Keyword (fr)
- Antivenin Cycle 5 chaînons Cytotoxicité Dérivé du benzène Dérivé du triazole Erythrocyte Hémolyse Hétérocycle azote Ophidia Origine animale Prévention Relation structure activité Synthèse chimique Toxicité Toxique Venin 1,2,3-Triazole-4-carboxylique acide(1-arènesulfonylamino-5-méthyl) ester éthyle Lachesis muta Reptilia Vertebrata
- Keyword (en)
- Antivenom Five membered ring Cytotoxicity Benzene derivatives Triazole derivatives Red blood cell Hemolysis Nitrogen heterocycle Ophidia Animal origin Prevention Structure activity relation Chemical synthesis Toxicity Poison Venom Reptilia Vertebrata
- Keyword (es)
- Antiveneno Ciclo 5 eslabones Citotoxicidad Benceno derivado Triazol derivado Eritrocito Hemólisis Heterociclo nitrógeno Ophidia Origen animal Prevención Relación estructura actividad Síntesis química Toxicidad Tóxico Veneno Reptilia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology / 002B03I Animal poisons toxicology. Antivenoms
- Discipline
- Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22059812
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2009.09.031 
https://dx.doi.org/10.1016/j.bmc.2009.09.031
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