Structure-Based Optimization of Arylamides as Inhibitors of Soluble Epoxide Hydrolase
- Author
- ELDRUP, Anne B1 ; SOLEYMANZADEH, Fariba1 ; TAYLOR, Steven J1 ; MUEGGE, Ingo1 ; FARROW, Neil A1 ; JOSEPH, David2 ; MCKELLOP, Keith3 ; MAN, Chuk C1 ; KUKULKA, Alison1 ; DE LOMBAERT, Stéphane1
[1] Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, United States
[2] Department of Drug Discovery Support, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, United States
[3] Department of Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, United States - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 19, pp 5880-5895, 16 p ; ref : 27 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Carboxamide Complexe enzyme inhibiteur Diffraction RX Dérivé de la benzamide Ether hydrolases Fluor Composé organique In vitro In vivo Inhibiteur Nitrile Optimisation Rat Relation structure activité Structure cristalline Structure moléculaire Sulfone Synthèse chimique Voie orale Benzamide(4-cyano-N-[3-(4-fluorophényl)-3-(4-mésylphényl)propyl]) Soluble epoxide hydrolase Stabilité métabolique Enzyme Hydrolases Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Carboxamide Inhibitor enzyme complex X ray diffraction Benzamide derivatives Ether hydrolases Fluorine Organic compounds In vitro In vivo Inhibitor Nitrile Optimization Rat Structure activity relation Crystalline structure Molecular structure Sulfone Chemical synthesis Oral administration Soluble epoxide hydrolase Metabolic stability Enzyme Hydrolases Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Carboxamida Complejo enzima inhibidor Difracción RX Benzamida derivado Ether hydrolases Fluor Compuesto orgánico In vitro In vivo Inhibidor Nitrilo Optimización Rata Relación estructura actividad Estructura cristalina Estructura molecular Sulfona Síntesis química Vía oral Enzima Hydrolases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F09 Miscellaneous
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22068424
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9005302 
https://dx.doi.org/10.1021/jm9005302
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