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1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: Potent, Selective, and Orally Efficacious Norepinephrine Reuptake Inhibitors

Author
PUWEN ZHANG1 ; TEREFENKO, Eugene A1 ; MUGFORD, Cheryl A3 ; TRYBULSKI, Eugene J1 ; VU, An T1 ; WHITESIDE, Garth T4 ; MAHANEY, Paige E1 ; BRAY, Jenifer2 ; DEECHER, Darlene2 ; FENSOME, Andrew1 ; HARRISON, Jim4 ; KIM, Callain1 ; KOURY, Elizabeth2 ; MARK, Lilly4 ; MCCOMAS, Casey C1
[1] Chemical Sciences, Wyeth Research, S-2250B, 500 Arcola Road, Collegeville, Pennsylvania 19426, United States
[2] Musculoskeletal Biology, Wyeth Research, S-2250B, 500 Arcola Road, Collegeville, Pennsylvania 19426, United States
[3] Drug Safety and Metabolism, Wyeth Research, S-2250B, 500 Arcola Road, Collegeville, Pennsylvania 19426, United States
[4] Neurosciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, United States
Source

Journal of medicinal chemistry (Print). 2009, Vol 52, Num 18, pp 5703-5711, 9 p ; ref : 61 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Columbus, OH
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Analgésique Animal Chimiothérapie Douleur neuropathique Dérivé du benzimidazole Hyperalgésie In vitro In vivo Inhibiteur recapture Inhibition Neurotransmetteur Noradrénaline Pharmacocinétique Rat Relation structure activité Synthèse chimique Sélectivité Traitement Transport membranaire Voie intraveineuse Voie orale Benzimidazol-2-one(1-éthyl-3-[1-(3-fluorophényl)-2-hydroxy-3-(méthylamino)propyl]) Benzimidazol-2-one(7-fluoro-1-[1-(3-fluorophényl)-2-hydroxy-3-(méthylamino)propyl]-3-isopropyl) Transporteur noradrénaline Mammalia Rodentia Vertebrata
Keyword (en)
Analgesic Animal Chemotherapy Neuropathic pain Benzimidazole derivatives Hyperalgesia In vitro In vivo Reuptake inhibitor Inhibition Neurotransmitter Norepinephrine Pharmacokinetics Rat Structure activity relation Chemical synthesis Selectivity Treatment Membrane transport Intravenous administration Oral administration Mammalia Rodentia Vertebrata
Keyword (es)
Analgésico Animal Quimioterapia Dolor neuropática Benzimidazol derivado Hiperalgesia In vitro In vivo Inhibidor recaptura Inhibición Neurotransmisor Noradrenalina Farmacocinética Rata Relación estructura actividad Síntesis química Selectividad Tratamiento Transporte membranal Vía intravenosa Vía oral Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22070217

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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