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Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors

Author
AL-TEL, Tateb H1 ; AL-QAWASMEH, Raed A2 ; SCHMIDT, Marco F3 ; AL-ABOUDI, Amal2 ; RAO, Shashidhar N4 ; SABRI, Salim S1 ; VOELTER, Wolfgang5
[1] College of Pharmacy, University of sharjah, P.O. Box 27272, Sharjah, United Arab Emirates
[2] Department of Chemistry, University of Jordan, Amman 1194, Jordan
[3] Leibniz-lnstitute of Molecular Pharmacology (FMP), Robert-Rossle-Strasse 10, 13125 Berlin, Germany
[4] Schrodinger, 120 W. 45th Street, New York, New York 10036, United States
[5] Interfakultares Institut fur Biochemie, Eberhard-Karls-Universitat Tuebingen, Hoppe-Seyler-Strasse, 72076 Tuebingen, Germany
Source

Journal of medicinal chemistry (Print). 2009, Vol 52, Num 20, pp 6484-6488, 5 p ; ref : 10 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Columbus, OH
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Activité biologique Antialzheimer Aspartic endopeptidases Carboxamide Dérivé de la dibenzodiazépine Fluor Composé organique In vitro Inhibiteur enzyme Lactame Molécule petite Protéine précurseur amyloïde Synthèse chimique β-secretase Dibenzo[b,e][1,4]diazépine dérivé Dibenzo[b,e][1,4]diazépine-3-carboxamide(10,11-dihydro-N-[4-fluorophényl]-11-oxo) Inhibiteur BACE Enzyme Hydrolases Peptidases
Keyword (en)
Biological activity Antialzheimer agent Aspartic endopeptidases Carboxamide Dibenzodiazepine derivatives Fluorine Organic compounds In vitro Enzyme inhibitor Lactam Small molecule Amyloid precursor protein Chemical synthesis β-secretase Enzyme Hydrolases Peptidases
Keyword (es)
Actividad biológica Antialzheimer Aspartic endopeptidases Carboxamida Dibenzodiazepina derivado Fluor Compuesto orgánico In vitro Inhibidor enzima Lactamo Molécula pequeña Proteína precursor amiloide Síntesis química β-secretase Enzima Hydrolases Peptidases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)

Francis
770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…

Discipline
Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
Origin
Inist-CNRS
Database
FRANCIS ; PASCAL
INIST identifier
22081693

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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