Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors
- Author
- AL-TEL, Tateb H1 ; AL-QAWASMEH, Raed A2 ; SCHMIDT, Marco F3 ; AL-ABOUDI, Amal2 ; RAO, Shashidhar N4 ; SABRI, Salim S1 ; VOELTER, Wolfgang5
[1] College of Pharmacy, University of sharjah, P.O. Box 27272, Sharjah, United Arab Emirates
[2] Department of Chemistry, University of Jordan, Amman 1194, Jordan
[3] Leibniz-lnstitute of Molecular Pharmacology (FMP), Robert-Rossle-Strasse 10, 13125 Berlin, Germany
[4] Schrodinger, 120 W. 45th Street, New York, New York 10036, United States
[5] Interfakultares Institut fur Biochemie, Eberhard-Karls-Universitat Tuebingen, Hoppe-Seyler-Strasse, 72076 Tuebingen, Germany - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 20, pp 6484-6488, 5 p ; ref : 10 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Antialzheimer Aspartic endopeptidases Carboxamide Dérivé de la dibenzodiazépine Fluor Composé organique In vitro Inhibiteur enzyme Lactame Molécule petite Protéine précurseur amyloïde Synthèse chimique β-secretase Dibenzo[b,e][1,4]diazépine dérivé Dibenzo[b,e][1,4]diazépine-3-carboxamide(10,11-dihydro-N-[4-fluorophényl]-11-oxo) Inhibiteur BACE Enzyme Hydrolases Peptidases
- Keyword (en)
- Biological activity Antialzheimer agent Aspartic endopeptidases Carboxamide Dibenzodiazepine derivatives Fluorine Organic compounds In vitro Enzyme inhibitor Lactam Small molecule Amyloid precursor protein Chemical synthesis β-secretase Enzyme Hydrolases Peptidases
- Keyword (es)
- Actividad biológica Antialzheimer Aspartic endopeptidases Carboxamida Dibenzodiazepina derivado Fluor Compuesto orgánico In vitro Inhibidor enzima Lactamo Molécula pequeña Proteína precursor amiloide Síntesis química β-secretase Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22081693
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9008482 
https://dx.doi.org/10.1021/jm9008482
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