Pyrano[3,2-c]quinoline―6-Chlorotacrine Hybrids as a Novel Family of Acetylchotinesterase-and β-Amyloid-Directed Anti-Alzheimer Compounds
- Author
- CAMPS, Pelayo1 ; FORMOSA, Xavier1 ; BARTOLINI, Manuela5 ; MANCINI, Francesca5 ; ANDRISANO, Vincenza5 ; ARCE, Mariana P6 ; ISABEL RODRIGUEZ-FRANCO, M6 ; HUERTAS, Oscar7 ; DAFNI, Thomai7 ; JAVIER LUQUE, F7 ; GALDEANO, Carles1 ; MUNOZ-TORRERO, Diego1 ; RAMIREZ, Lorena1 ; GOMEZ, Elena2 ; ISAMBERT, Nicolás2 ; LAVILLA, Rodolfo2 3 ; BADIA, Albert4 ; VICTORIA CLOS, M4
[1] Laboratori de Quimica Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain
[2] Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10-12, 08028, Barcelona, Spain
[3] Laboratori de Quimica Orgànica, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII, s/n, 08028, Barcelona, Spain
[4] Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain
[5] Department of Pharmaceutical Sciences, Alma Mater Studiorum, Bologna University, Via Belmeloro 6, 40126, Bologna, Italy
[6] Institute de Quimica Médica (CSIC), Juan de la Cierva, 3, 28006, Madrid, Spain
[7] Departament de Fisicoquimica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 17, pp 5365-5379, 15 p ; ref : 60 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acetylcholinesterase Antialzheimer Aspartic endopeptidases Barrière hématoencéphalique Carboxamide Chlore Composé organique Complexe enzyme inhibiteur Composé aromatique Composé tricyclique Dérivé de l'acridine Dérivé du benzène Hétérocycle azote Hétérocycle oxygène azote In vitro Inhibiteur enzyme Modèle moléculaire Modélisation Protéine amyloïde β Protéine précurseur amyloïde Pénétration Relation structure activité Synthèse chimique Système nerveux central Inhibiteur BACE1 Memapsin 2 Pyrano[3,2-c]quinoléine-9-propionamide dérivé Pyranoquinoléine Tacrine dérivé Carboxylic ester hydrolases Enzyme Esterases Hydrolases Peptidases
- Keyword (en)
- Acetylcholinesterase Antialzheimer agent Aspartic endopeptidases Blood brain barrier Carboxamide Chlorine Organic compounds Inhibitor enzyme complex Aromatic compound Tricyclic compound Acridine derivatives Benzene derivatives Nitrogen heterocycle Oxygen nitrogen heterocycle In vitro Enzyme inhibitor Molecular model Modeling β Amyloid protein Amyloid precursor protein Penetration Structure activity relation Chemical synthesis Central nervous system Carboxylic ester hydrolases Enzyme Esterases Hydrolases Peptidases
- Keyword (es)
- Acetylcholinesterase Antialzheimer Aspartic endopeptidases Barrera hematoencefálica Carboxamida Cloro Compuesto orgánico Complejo enzima inhibidor Compuesto aromático Compuesto tricíclico Acridina derivado Benceno derivado Heterociclo nitrógeno Heterociclo oxígeno nitrógeno In vitro Inhibidor enzima Modelo molecular Modelización Proteína amiloide β Proteína precursor amiloide Penetración Relación estructura actividad Síntesis química Sistema nervioso central Carboxylic ester hydrolases Enzima Esterases Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22098165
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm900859q 
https://dx.doi.org/10.1021/jm900859q
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