2-Arylamino-4-Amino-5-Aroylthiazoles. One-Pot Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization
- Author
- ROMAGNOLI, Romeo1 ; GIOVANNI BARALDI, Pier1 ; SELLMER, Andreas5 ; BRANCALE, Andrea4 ; HAMEL, Ernest6 ; DORA CARRION, Maria1 ; CRUZ-LOPEZ, Olga1 ; LOPEZ CARA, Carlota1 ; BASSO, Giuseppe2 ; VIOLA, Giampietro2 ; KHEDR, Mohammed4 ; BALZARINI, Jan3 ; MAHBOOBI, Siavosh5
[1] Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy
[2] Dipartimento di Pediatria, Laboratorio di Oncoematologia, Università di Padova, 35131 Padova, Italy
[3] Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Minderbroedersstraat 10, 3000 Leuven, Belgium
[4] The Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, United Kingdom
[5] Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany
[6] Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, United States - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 17, pp 5551-5555, 5 p ; ref : 12 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Antimitotique Antitubuline Apoptose Cellule tumorale Col utérus Cycle 5 chaînons Cytotoxicité Cétone Dérivé du benzène Glande mammaire Homme Hétérocycle soufre azote In vitro Leucémie Lignée HeLa Lignée L1210 Lignée cellulaire Mort cellulaire Relation structure activité Souris Synthèse chimique Lignée FM3A Lignée MOLT4 Thiazole(4-amino-5-aroyl-2-arylamino) Mammalia Rodentia Vertebrata
- Keyword (en)
- Antineoplastic agent Antimitotic Antitubulin Apoptosis Tumor cell Uterine cervix Five membered ring Cytotoxicity Ketone Benzene derivatives Mammary gland Human Sulfur nitrogen heterocycle In vitro Leukemia Hela cell line L1210 cell line Cell line Cell death Structure activity relation Mouse Chemical synthesis Mammalia Rodentia Vertebrata
- Keyword (es)
- Anticanceroso Antimitótico Antitubulina Apoptosis Célula tumoral Cuello útero Ciclo 5 eslabones Citotoxicidad Cetona Benceno derivado Glándula mamaria Hombre Heterociclo azufre nitrógeno In vitro Leucemia Célula HeLa Célula L1210 Línea celular Muerte celular Relación estructura actividad Ratón Síntesis química Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22098181
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9001692 
https://dx.doi.org/10.1021/jm9001692
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