Quantitative structure-activity relationship analysis of aryl alkanol piperazine derivatives with antidepressant activities
- Author
- CHEN, Ke-Xian1 ; LI, Zu-Guang1 ; XIE, Hai-Ying1 ; GAO, Jian-Rong1 ; ZOU, Jian-Wei2
[1] College of Chemical Engineering and Materials Science, Zhejiang University of Technology, 18,Chaowang Road, Hangzhou 310014, China
[2] Key Laboratory for Molecular Design and Nutrition Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315104, China - Source
European journal of medicinal chemistry. 2009, Vol 44, Num 11, pp 4367-4375, 9 p ; ref : 40 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antidepressant activities Aryl alkanol piperazine derivatives Genetic function approximation (GFA) Genetic partial least squares (G/PLS) Molecular field analysis (MFA) Quantitative structure-activity relationship (QSAR)
- Keyword (fr)
- Activité biologique Alcool Algorithme génétique Antidépresseur Chlore Composé organique Dérivé de la pipérazine Dérivé du naphtalène Modèle moléculaire Prédiction Psychotrope Relation structure activité Propan-1-ol(1-[5-chloro-6-méthoxy-2-naphtyl]-2-[4-(2-méthoxyphényl)pipérazino]) QSAR
- Keyword (en)
- Biological activity Alcohol Genetic algorithm Antidepressant agent Chlorine Organic compounds Piperazine derivatives Naphthalene derivatives Molecular model Prediction Psychotropic Structure activity relation
- Keyword (es)
- Actividad biológica Alcohol Algoritmo genético Antidepresor Cloro Compuesto orgánico Piperazina derivado Naftaleno derivado Modelo molecular Predicción Psicotropo Relación estructura actividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22124187
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2009.05.029 
https://dx.doi.org/10.1016/j.ejmech.2009.05.029
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