3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3
- Author
- HAVRAN, Lisa M1 ; CHONG, Dan C1 ; KAPOOR, Bhupesh2 ; WEIXIN XU3 ; MOSYAK, Lidia3 ; MOY, Franklin3 ; HUM, Wah-Tung3 ; WOOD, Andrew4 ; ROBICHAUD, Albert J1 ; CHILDERS, Wayne E1 ; DOLLINGS, Paul J1 ; DIETRICH, Arlene1 ; HARRISON, Boyd L1 ; MARATHIAS, Vasilios1 ; TAWA, Gregory1 ; AULABAUGH, Ann2 ; COWLING, Rebecca2
[1] Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, United States
[2] Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, United States
[3] Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, United States
[4] Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, United States - Source
Bioorganic & medicinal chemistry. 2009, Vol 17, Num 22, pp 7755-7768, 14 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Apoptosis Caspase-3 Pyrimidoindolone Stroke
- Keyword (fr)
- Accident cérébrovasculaire Apoptose Caspase Composé non peptide Cysteine endopeptidases Dérivé du pyrrole Inhibiteur Modèle moléculaire Modélisation Relation structure activité Spirane Sulfonamide Synthèse chimique Pyrimido[1,2-a]indol-10-one dérivé Pyrimido[1,2-a]indole dérivé Spiro[cyclopentane-1:3p-pyrimido[1,2-a]indole] dérivé Enzyme Hydrolases Peptidases
- Keyword (en)
- Stroke Apoptosis Caspase Non peptide compound Cysteine endopeptidases Pyrrole derivatives Inhibitor Molecular model Modeling Structure activity relation Spiran Sulfonamide Chemical synthesis Enzyme Hydrolases Peptidases
- Keyword (es)
- Accidente cerebrovascular Apoptosis Caspase Compuesto no péptido Cysteine endopeptidases Pirrol derivado Inhibidor Modelo molecular Modelización Relación estructura actividad Espirano Sulfonamida Síntesis química Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B11 Miscellaneous
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F09 Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22139517
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2009.09.036 
https://dx.doi.org/10.1016/j.bmc.2009.09.036
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