2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
- Author
- LEDEBOER, Mark W1 ; PIERCE, Albert C1 ; SHLYAKTER, Dina1 ; MAHAJAN, Sudipta1 ; HOOCK, Thomas1 ; BIN FAN1 ; TSAI, Wan-Jung1 ; KOLACZKOWSKI, Elaine1 ; CARRIER, Scott1 ; HOGAN, James K1 ; ZESSIS, Richard1 ; PAZHANISAMY, S1 ; DUFFY, John P1 ; BENNANI, Youssef L; HUAI GAO1 ; MESSERSMITH, David1 ; SALITURO, Francesco G1 ; NANTHAKUMAR, Suganthini1 ; COME, Jon1 ; ZUCCOLA, Harmon J1 ; SWENSON, Lora1
[1] Vertex Pharmaceuticals Inc., Cambridge, MA 02139-4242, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6529-6533, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2-Amino-pyrazolo[1,5-a]pyrimidines JAK2 Janus kinase 2 Kinase inhibitor Polycythemia vera Structure based design
- Keyword (fr)
- Amine Animal Dérivé de la pyrimidine Fluor Composé organique In vitro In vivo Inhibiteur Pharmacocinétique Polyglobulie vraie Pyrazolopyrimidine dérivé Rat Relation structure activité Synthèse chimique Sélectivité Transferases Voie intraveineuse Non-specific protein-tyrosine kinase Pyrazolo[1,5-a]pyrimidine dérivé Pyrazolo[1,5-a]pyrimidine(2-amino-3-[4-(1-[4-fluorophényl]butylamino)pyrimidin-6-yl]) Enzyme Hémopathie Mammalia Rodentia Syndrome myéloprolifératif Vertebrata
- Keyword (en)
- Amine Animal Pyrimidine derivatives Fluorine Organic compounds In vitro In vivo Inhibitor Pharmacokinetics Polycythemia vera Pyrazolopyrimidine derivatives Rat Structure activity relation Chemical synthesis Selectivity Transferases Intravenous administration Non-specific protein-tyrosine kinase Enzyme Hemopathy Mammalia Rodentia Myeloproliferative syndrome Vertebrata
- Keyword (es)
- Amina Animal Pirimidina derivado Fluor Compuesto orgánico In vitro In vivo Inhibidor Farmacocinética Policitemia vera Pyrazolopirimidina derivado Rata Relación estructura actividad Síntesis química Selectividad Transferases Vía intravenosa Enzima Hemopatía Mammalia Rodentia Mieloproliferativo síndrome Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22153677
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.10.053 
https://dx.doi.org/10.1016/j.bmcl.2009.10.053
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