1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)
- Author
- THERRIEN, Eric1 ; LAROUCHE, Guillaume1 ; WAHHAB, Amal1 ; MANKU, Sukhdev1 ; ALLAN, Martin1 ; NGUYEN, Natalie1 ; STYHLER, Sylvia2 ; ROBERT, Marie-France2 ; GOULET, Anne-Christine2 ; BESTERMAN, Jeffrey M2 ; NGUYEN, Hannah2
[1] MethylGene Inc., Department of Medicinal Chemistry, 7220 rue Frederick-Banting, Montreal, Quebec, H4S 2A1, Canada
[2] MethylGene Inc., Department of Pharmacology and Cell Biology, 7220 rue Frederick-Banting, Montreal, Quebec, H4S 2A1, Canada - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6725-6732, 8 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- CARM1 inhibitors Co-activator associated arginine Histone methyltransferase inhibitors PRMT4 inhibitors methyltransferase 1
- Keyword (fr)
- Animal Carboxamide Diamine Dérivé du pyrazole Fluor Composé organique Histone-arginine N-methyltransferase In vitro In vivo Inhibiteur enzyme Pharmacocinétique Rat Relation structure activité Synthèse chimique Voie intraveineuse Voie orale Pyrazole-3-carboxamide(2-aryl-N-[2-méthoxybenzyl]-5-trifluorométhyl) Enzyme Mammalia Methyltransferases Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Carboxamide Diamine Pyrazole derivatives Fluorine Organic compounds Histone-arginine N-methyltransferase In vitro In vivo Enzyme inhibitor Pharmacokinetics Rat Structure activity relation Chemical synthesis Intravenous administration Oral administration Enzyme Mammalia Methyltransferases Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Carboxamida Diamina Pirazol derivado Fluor Compuesto orgánico Histone-arginine N-methyltransferase In vitro In vivo Inhibidor enzima Farmacocinética Rata Relación estructura actividad Síntesis química Vía intravenosa Vía oral Enzima Mammalia Methyltransferases Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22153722
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.09.110 
https://dx.doi.org/10.1016/j.bmcl.2009.09.110
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