Identification and Structure-Activity Relationships of Chromene-Derived Selective Estrogen Receptor Modulators for Treatment of Postmenopausal Symptoms
- Author
- JAIN, Nareshkumar1 ; JIAYI XU1 ; XUN LI1 ; HAHN, Dowon1 ; COUSINEAU, Martin1 ; PENG, Sean1 ; RITCHIE, David1 ; RUSSELL, Ronald1 ; LUNDEEN, Scott1 ; ZHIHUA SUI1 ; KANOJIA, Ramesh M1 ; FUYONG DU1 ; GUO, Jian-Zhong1 ; PACIA, Emmanuel1 ; LAI, Muh-Tsann1 ; MUSTO, Amy1 ; ALLAN, George1 ; REUMAN, Michael1
[1] Johnson & Johnson Pharmaceutical Research & Development LLC, 665 Stockton Drive, Exton, Pennsylvania 19341, United States - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 23, pp 7544-7569, 26 p ; ref : 18 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Aminoéther Animal Cellule tumorale Composé aromatique Composé tétracyclique Endomètre Ether Fixation biologique Glande mammaire Homme Hétérocycle oxygène In vitro In vivo Ligand Lignée cellulaire Modulateur sélectif des récepteurs aux oestrogènes Pharmacocinétique Phénols Postménopause Rat Relation structure activité Récepteur hormonal Récepteur oestrogène Synthèse chimique Traitement Voie orale Benzopyranobenzooxépine Lignée Ishikawa Lignée MCF7 [1]Benzopyrano[4,3-d][1]benzooxépine dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Aminoether Animal Tumor cell Aromatic compound Tetracyclic compound Endometrium Ether Biological fixation Mammary gland Human Oxygen heterocycle In vitro In vivo Ligand Cell line Selective estrogen receptor modulator Pharmacokinetics Phenols Postmenopause Rat Structure activity relation Hormonal receptor Estrogen receptor Chemical synthesis Treatment Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Aminoeter Animal Célula tumoral Compuesto aromático Compuesto tetracíclico Endometrio Eter Fijación biológica Glándula mamaria Hombre Heterociclo oxígeno In vitro In vivo Ligando Línea celular Modulador selectivo del receptor de estrógeno Farmacocinética Fenoles Postmenopausia Rata Relación estructura actividad Receptor hormonal Receptor estrógeno Síntesis química Tratamiento Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22208039
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm900146e 
https://dx.doi.org/10.1021/jm900146e
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