3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ
- Author
- PEIFER, Christian1 3 ; ABADLEH, Mohammed1 ; BISCHOF, Joachim2 ; HAUSER, Dominik1 4 ; SCHATTEL, Verena1 ; HIRNER, Heidrun2 ; KNIPPSCHILD, Uwe2 ; LAUFER, Stefan1
[1] Department of Pharmacy, Eberhard-Karls-University, Aufder Morgenstelle 8, 72076 Tuebingen, Germany
[2] Department of General Visceral and Transplantation Surgery, Surgery Centre, University of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany
[3] MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DDI 5EH, Scotland, United Kingdom
[4] c-a-i-r biosciences GmbH, Paul-Ehrlich-Strasse 15, 72076 Tuebingen, Germany - Source
Journal of medicinal chemistry (Print). 2009, Vol 52, Num 23, pp 7618-7630, 13 p ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Columbus, OH
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiinflammatoire Carboxamide Complexe enzyme inhibiteur Dérivé de l'imidazole Dérivé de la pyridine Dérivé du benzène Ether Hétérocycle azote Hétérocycle oxygène azote In vitro Inhibiteur enzyme Mitogen-activated protein kinase Modèle moléculaire Modélisation Non-specific serine/threonine protein kinase Relation structure activité Synthèse chimique Transduction signal Benzèneacétamide(4-fluoro-N-[4-(3-[4-fluorophényl]-5-isopropylisoxazol-4-yl)-2-pyridyl]) CKP 138 Cinnamamide(2,4-diméthoxy-N-[4-(4-[4-fluorophényl]-2-mésylimidazol-5-yl)-2-pyridyl]) Inhibiteur p38 Isoxazole(3-[4-fluorophényl]-5-isopropyl-4-[2-([1-phényléthyl]amino)-4-pyridyl]) Enzyme Fluor Composé organique Transferases
- Keyword (en)
- Antiinflammatory agent Carboxamide Inhibitor enzyme complex Imidazole derivatives Pyridine derivatives Benzene derivatives Ether Nitrogen heterocycle Oxygen nitrogen heterocycle In vitro Enzyme inhibitor Mitogen-activated protein kinase Molecular model Modeling Non-specific serine/threonine protein kinase Structure activity relation Chemical synthesis Signal transduction Enzyme Fluorine Organic compounds Transferases
- Keyword (es)
- Antiinflamatorio Carboxamida Complejo enzima inhibidor Imidazol derivado Piridina derivado Benceno derivado Eter Heterociclo nitrógeno Heterociclo oxígeno nitrógeno In vitro Inhibidor enzima Mitogen-activated protein kinase Modelo molecular Modelización Non-specific serine/threonine protein kinase Relación estructura actividad Síntesis química Transducción señal Enzima Fluor Compuesto orgánico Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E02 Oxidoreductases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22208044
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm9005127 
https://dx.doi.org/10.1021/jm9005127
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:2:\"23\";s:8:\"\u0000*\u0000spage\";s:4:\"7618\";s:8:\"\u0000*\u0000epage\";s:4:\"7630\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"PEIFER\";s:10:\"\u0000*\u0000aufirst\";s:9:\"Christian\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:17:\"ABADLEH, Mohammed\";i:1;s:16:\"BISCHOF, Joachim\";i:2;s:15:\"HAUSER, Dominik\";i:3;s:16:\"SCHATTEL, Verena\";i:4;s:15:\"HIRNER, Heidrun\";i:5;s:16:\"KNIPPSCHILD, Uwe\";i:6;s:14:\"LAUFER, Stefan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:8:\"\u0000*\u0000place\";s:12:\"Columbus, OH\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:2:\"23\";s:8:\"\u0000*\u0000spage\";s:4:\"7618\";s:8:\"\u0000*\u0000epage\";s:4:\"7630\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"PEIFER\";s:10:\"\u0000*\u0000aufirst\";s:9:\"Christian\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:17:\"ABADLEH, Mohammed\";i:1;s:16:\"BISCHOF, Joachim\";i:2;s:15:\"HAUSER, Dominik\";i:3;s:16:\"SCHATTEL, Verena\";i:4;s:15:\"HIRNER, Heidrun\";i:5;s:16:\"KNIPPSCHILD, Uwe\";i:6;s:14:\"LAUFER, Stefan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:8:\"\u0000*\u0000place\";s:12:\"Columbus, OH\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:2:\"23\";s:8:\"\u0000*\u0000spage\";s:4:\"7618\";s:8:\"\u0000*\u0000epage\";s:4:\"7630\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"PEIFER\";s:10:\"\u0000*\u0000aufirst\";s:9:\"Christian\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:17:\"ABADLEH, Mohammed\";i:1;s:16:\"BISCHOF, Joachim\";i:2;s:15:\"HAUSER, Dominik\";i:3;s:16:\"SCHATTEL, Verena\";i:4;s:15:\"HIRNER, Heidrun\";i:5;s:16:\"KNIPPSCHILD, Uwe\";i:6;s:14:\"LAUFER, Stefan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:8:\"\u0000*\u0000place\";s:12:\"Columbus, OH\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:2:\"23\";s:8:\"\u0000*\u0000spage\";s:4:\"7618\";s:8:\"\u0000*\u0000epage\";s:4:\"7630\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"PEIFER\";s:10:\"\u0000*\u0000aufirst\";s:9:\"Christian\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:17:\"ABADLEH, Mohammed\";i:1;s:16:\"BISCHOF, Joachim\";i:2;s:15:\"HAUSER, Dominik\";i:3;s:16:\"SCHATTEL, Verena\";i:4;s:15:\"HIRNER, Heidrun\";i:5;s:16:\"KNIPPSCHILD, Uwe\";i:6;s:14:\"LAUFER, Stefan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:8:\"\u0000*\u0000place\";s:12:\"Columbus, OH\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm9005127\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2009\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:2:\"23\";s:8:\"\u0000*\u0000spage\";s:4:\"7618\";s:8:\"\u0000*\u0000epage\";s:4:\"7630\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"PEIFER\";s:10:\"\u0000*\u0000aufirst\";s:9:\"Christian\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:17:\"ABADLEH, Mohammed\";i:1;s:16:\"BISCHOF, Joachim\";i:2;s:15:\"HAUSER, Dominik\";i:3;s:16:\"SCHATTEL, Verena\";i:4;s:15:\"HIRNER, Heidrun\";i:5;s:16:\"KNIPPSCHILD, Uwe\";i:6;s:14:\"LAUFER, Stefan\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:127:\"3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38\u03b1 Mitogen Activated Protein Kinase and Casein Kinase 1\u03b4\";s:8:\"\u0000*\u0000place\";s:12:\"Columbus, OH\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
