2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study
- Author
- BASNET, Arjun1 ; THAPA, Pritam1 ; KWON, Youngjoo4 ; LEE, Chong-Soon5 ; LEE, Eung-Seok1 ; KARKI, Radha1 ; CHOI, Hoyoung1 ; JAE HUN CHOI1 ; MINHO YUN1 ; JEONG, Byeong-Seon1 ; JAHNG, Yurngdong1 ; NA, Younghwa2 ; CHO, Won-Jea3
[1] College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea, Republic of
[2] College of Pharmacy, Catholic University of Daegu, Kyongsan 712-702, Korea, Republic of
[3] College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea, Republic of
[4] College of Pharmacy, Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea, Republic of
[5] Department of Biochemistry, Yeungnam University, Kyongsan 712-749, Korea, Republic of - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 1, pp 42-47, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2,6-Dithienyl-4-furyl pyridine Antitumor agents Cytotoxicity Docking study Topoisomerase I and II inhibitor
- Keyword (fr)
- Anticancéreux Cellule tumorale Col utérus Complexe enzyme inhibiteur Cycle 5 chaînons Cycle 6 chaînons Cytotoxicité Côlon DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Dérivé du furane Dérivé du thiophène Glande mammaire Homme Hétérocycle azote Hétérocycle oxygène Hétérocycle soufre In vitro Inhibiteur enzyme Lignée HeLa Lignée cellulaire Modèle moléculaire Modélisation Prostate Relation structure activité Synthèse chimique Tumeur solide Lignée DU145 Lignée HCT116 Lignée MCF7 Lignée MDAMB231 Pyridine(2,6-bis[3-méthyl-2-thiényl]-4-[2-furyl]) Enzyme Isomerases
- Keyword (en)
- Antineoplastic agent Tumor cell Uterine cervix Inhibitor enzyme complex Five membered ring Six membered ring Cytotoxicity Colon DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Furan derivatives Thiophene derivatives Mammary gland Human Nitrogen heterocycle Oxygen heterocycle Sulfur heterocycle In vitro Enzyme inhibitor Hela cell line Cell line Molecular model Modeling Prostate Structure activity relation Chemical synthesis Solid tumor Enzyme Isomerases
- Keyword (es)
- Anticanceroso Célula tumoral Cuello útero Complejo enzima inhibidor Ciclo 5 eslabones Ciclo 6 eslabones Citotoxicidad Colón DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Furano derivado Tiofeno derivado Glándula mamaria Hombre Heterociclo nitrógeno Heterociclo oxígeno Heterociclo azufre In vitro Inhibidor enzima Célula HeLa Línea celular Modelo molecular Modelización Prostata Relación estructura actividad Síntesis química Tumor sólido Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22314184
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.11.041 
https://dx.doi.org/10.1016/j.bmcl.2009.11.041
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