2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly
- Author
- XUEJUN ZHU1 2 ; GUOMING ZHAO2 ; XIAOPING ZHOU1 ; XIAOQIAN XU2 3 ; GUANGQIANG XIA2 ; ZHIBING ZHENG2 ; LILI WANG2 ; XIAOHONG YANG1 ; SONG LI2
[1] School of Pharmacy, Jilin University, Changchun 130021, China
[2] Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
[3] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 1, pp 299-301, 3 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one Hepatitis B virus (HBV) Inhibitor Nucleocapsid assembly
- Keyword (fr)
- Antiviral Capside Composé bicyclique Dérivé de la pyrazine Dérivé de la pyridine Dérivé du benzène Enveloppe virus Hétérocycle azote In vitro Inhibition Nucléocapside Relation structure activité Synthèse chimique Virus hépatite B Quinazol-5-one(4-[2-chloro-4-fluorophényl]-7,7-diméthyl-2-[3-pyridyl]-4,6,7,8-tétrahydro) Chlore Composé organique Fluor Composé organique Hepadnaviridae Orthohepadnavirus Virus
- Keyword (en)
- Antiviral Capsid Bicyclic compound Pyrazine derivatives Pyridine derivatives Benzene derivatives Virus envelope Nitrogen heterocycle In vitro Inhibition Nucleocapsid Structure activity relation Chemical synthesis Hepatitis B virus Chlorine Organic compounds Fluorine Organic compounds Hepadnaviridae Orthohepadnavirus Virus
- Keyword (es)
- Antiviral Cápside Compuesto bicíclico Pirazina derivado Piridina derivado Benceno derivado Cubierta virus Heterociclo nitrógeno In vitro Inhibición Nucleocápside Relación estructura actividad Síntesis química Hepatitis B virus Cloro Compuesto orgánico Fluor Compuesto orgánico Hepadnaviridae Orthohepadnavirus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22314244
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.10.119 
https://dx.doi.org/10.1016/j.bmcl.2009.10.119
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