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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

Author
ARGIRIADI, Maria A1 ; ERICSSON, Anna M1 ; KWAK, Silvia1 ; BIQIN LI1 ; MANKOVICH, John A1 ; MARCOTTE, Douglas1 ; MULLEN, Kelly D1 ; BAOFU NI1 ; PIETRAS, M1 ; SADHUKHAN, Ramkrishna1 ; SOUSA, Silvino1 ; TOMLINSON, Medha J1 ; HARRIS, Christopher M1 ; LU WANG; TAO XIANG; TALANIAN, Robert V; BANACH, David L1 ; BORHANI, David W1 ; CALDERWOOD, David J1 ; DEMERS, Megan D1 ; DIMAURO, Jennifer1 ; DIXON, Richard W1 ; HARDMAN, Jennifer1
[1] Abbott Laboratories, 100 Research Drive, Worcester, MA 01605-5314, United States
Source

Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 1, pp 330-333, 4 p

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
Diaminopyrimidine MAPKAP-K2 MK2 TNFα
Keyword (fr)
Activité biologique Antiinflammatoire Complexe enzyme inhibiteur Composé aromatique Cycle 6 chaînons Dérivé de la pyrimidine Dérivé du benzofurane Facteur nécrose tumorale α Hétérocycle azote Hétérocycle oxygène Hétérocycle soufre Inhibiteur enzyme Mitogen-activated protein kinase Mode liaison Modèle moléculaire Modélisation Benzo[b]thiophène-2-carboxamide(6-[5-([2-aminopyrimidin-4-yl]amino)-2-hydroxyphényl]-N-méthyl) Indazole5-[(2-aminopyrimidin-4-ylamino]-7-benzofur-2-yl) Phénol(4-[(2-aminopyrimidin-4-yl)amino]) Enzyme Transferases
Keyword (en)
Biological activity Antiinflammatory agent Inhibitor enzyme complex Aromatic compound Six membered ring Pyrimidine derivatives Benzofuran derivatives Tumor necrosis factor α Nitrogen heterocycle Oxygen heterocycle Sulfur heterocycle Enzyme inhibitor Mitogen-activated protein kinase Binding mode Molecular model Modeling Enzyme Transferases
Keyword (es)
Actividad biológica Antiinflamatorio Complejo enzima inhibidor Compuesto aromático Ciclo 6 eslabones Pirimidina derivado Factor necrosis tumoral α Heterociclo nitrógeno Heterociclo oxígeno Heterociclo azufre Inhibidor enzima Mitogen-activated protein kinase Modo de enlace Modelo molecular Modelización Enzima Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22314252

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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