2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety
- Author
- SMITH, Cameron J1 ; ALI, Amjad1 ; SPARROW, Carl P2 ; WRIGHT, Samuel D2 ; SINCLAIR, Peter J1 ; LIYA CHEN1 ; HAMMOND, Milton L1 ; ANDERSON, Matt S2 ; YING CHEN2 ; EVELAND, Suzanne S2 ; QIU GUO2 ; HYLAND, Sheryl A2 ; MILOT, Denise P2
[1] Department of Medicinal Chemistry, Merck Research Laboratories, Rahway NJ 07065, United States
[2] Department of Cardiovascular Diseases, Merck Research Laboratories, Rahway NJ 07065, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 1, pp 346-349, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Benzoxazole CETP Cholesteryl ester transfer protein HDL High density lipoprotein
- Keyword (fr)
- Alcool tertiaire Carboxamide Cholestérol HDL Composé aromatique Composé bicyclique Dérivé du benzène Glycoprotéine Hypolipémiant Hétérocycle oxygène azote In vitro Inhibiteur Lipoprotéine HDL Nitrile Protéine transport Relation structure activité Synthèse chimique Acétamide(N-[4-(5-cyano-7-[1-hydroxy-1-méthyléthyl]benzooxazol-2-yl)phényl]-2-o-tolyl) Benzooxazole-5-carbonitrile dérivé Protéine transport CETP
- Keyword (en)
- Tertiary alcohol Carboxamide Cholesterol HDL Aromatic compound Bicyclic compound Benzene derivatives Glycoprotein Antilipemic agent Oxygen nitrogen heterocycle In vitro Inhibitor Lipoprotein HDL Nitrile Carrier protein Structure activity relation Chemical synthesis
- Keyword (es)
- Alcohol terciario Carboxamida Colesterol HDL Compuesto aromático Compuesto bicíclico Benceno derivado Glicoproteína Hipolipemiante Heterociclo oxígeno nitrógeno In vitro Inhibidor Lipoproteina HDL Nitrilo Proteína transportador Relación estructura actividad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22314256
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.10.099 
https://dx.doi.org/10.1016/j.bmcl.2009.10.099
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