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2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Author
THAPA, Pritam1 ; KARKI, Radha1 ; THAPA, Uttam1 ; JAHNG, Yurngdong1 ; JUNG, Mi-Ja2 ; JUNG MIN NAM2 ; NA, Younghwa3 ; KWON, Youngjoo2 ; LEE, Eung-Seok1
[1] College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea, Republic of
[2] College of Pharmacy & Division of Life & Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea, Republic of
[3] College of Pharmacy, Catholic University of Daegu, Kyongsan 712-702, Korea, Republic of
Source

Bioorganic & medicinal chemistry. 2010, Vol 18, Num 1, pp 377-386, 10 p ; ref : 14 ref

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
2-(5-Chlorothiophen-2-yl)-4-(furan-3-yl) 2-Thienyl-4-furyl-6-aryl pyridine Cytotoxicity Topoisomerase I and II
Keyword (fr)
Anticancéreux Cellule tumorale Col utérus Cytotoxicité Côlon DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Dérivé de la pyridine Dérivé du benzène Dérivé du furane Dérivé du thiophène Glande mammaire Homme Hétérocycle azote Hétérocycle soufre In vitro Inhibiteur enzyme Leucémie Lignée HeLa Lignée cellulaire Prostate Relation structure activité Synthèse chimique Tumeur solide Lignée DU145 Lignée HCT15 Lignée K562 Lignée MCF7 Chlore Composé organique Enzyme Isomerases
Keyword (en)
Antineoplastic agent Tumor cell Uterine cervix Cytotoxicity Colon DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Pyridine derivatives Benzene derivatives Furan derivatives Thiophene derivatives Mammary gland Human Nitrogen heterocycle Sulfur heterocycle In vitro Enzyme inhibitor Leukemia Hela cell line Cell line Prostate Structure activity relation Chemical synthesis Solid tumor Chlorine Organic compounds Enzyme Isomerases
Keyword (es)
Anticanceroso Célula tumoral Cuello útero Citotoxicidad Colón DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase Piridina derivado Benceno derivado Furano derivado Tiofeno derivado Glándula mamaria Hombre Heterociclo nitrógeno Heterociclo azufre In vitro Inhibidor enzima Leucemia Célula HeLa Línea celular Prostata Relación estructura actividad Síntesis química Tumor sólido Cloro Compuesto orgánico Enzima Isomerases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22323829

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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