Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
- Author
- JIANMING ZHANG1 ; ADRIAN, Francisco J2 ; GUO, Gui-Rong2 ; QIANG DING2 ; OKRAM, Barun7 ; CHOI, Yongmun1 ; WOJCIECHOWSKI, Amy1 ; XIANMING DENG1 ; GUOXUN LIU2 ; FENDRICH, Gabriele3 ; STRAUSS, André3 ; VAJPAI, Navratna8 ; JAHNKE, Wolfgang3 ; GRZESIEK, Stephan8 ; TUNTLAND, Tove2 ; YI LIU2 ; BURSULAYA, Badry2 ; AZAM, Mohammad6 ; MANLEY, Paul W3 ; ENGEN, John R4 ; DALEY, George Q6 ; WARMUTH, Markus9 ; GRAY, Nathanael S1 ; COWAN-JACOB, Sandra W3 ; LI, Allen G2 ; IACOB, Roxana E4 ; SIM, Taebo1 5 ; POWERS, John6 ; DIERKS, Christine2 ; FANGXIAN SUN2
[1] Dana-Farber Cancer Institute, Harvard Medical School, Department of Cancer Biology and Department of Biological Chemistry and Molecular Pharmacology, 250 Longwood Avenue, Seeley G. Mudd Building 628, Boston, Massachusetts 02115, United States
[2] Genomics Institute of the Novartis Research Foundation, Department of Chemistry, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States
[3] Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland
[4] The Barnett Institute of Chemical & Biological Analysis and Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States
[5] Life Sciences Research Division, Korea Institute of Science and Technology 39-1, Hawolgok-dong, Seongbuk-gu, Seoul, 136-791, Korea, Republic of
[6] Division of Pediatric Hematology/Oncology, Children's Hospital and Dana-Farber Cancer Institute; Division of Hematology, Brigham and Women's Hospital; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Howard Hughes Medical Institute, Boston, Massachusetts 02115, United States
[7] Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
[8] Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
[9] Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States - Source
Nature (London). 2010, Vol 463, Num 7280, pp 501-506, 6 p ; ref : 38 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- ATP Ciblage Inhibiteur Site fixation
- Keyword (en)
- ATP Targeting Inhibitor Binding site
- Keyword (es)
- ATP Blancado Inhibidor Sitio fijación
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology
- Discipline
- Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22333406
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature08675 
https://dx.doi.org/10.1038/nature08675
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