2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A3 adenosine receptor-selective agonists
- Author
- TOSH, Dilip K1 ; CHINN, Moshe1 ; YOO, Lena S1 ; DONG WOOK KANG2 ; LUECKE, Hans2 ; GAO, Zhan-Guo1 ; JACOBSON, Kenneth A1
[1] Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, NIH, NIDDK, LBC, Bethesda, MD 20892, United States
[2] Gene Regulation Group, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 2, pp 508-517, 10 p ; ref : 38 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Azide G protein-coupled receptor Purines Radioligand binding Structure-activity relationship
- Keyword (fr)
- Acide uronique Agoniste Azide Carboxamide Chlore Composé organique Composé acétylénique Dérivé de l'adénine Dérivé de la purine In vitro Ligand Marquage radioisotopique Nucléoside Relation structure activité Récepteur adénosinique A3 Récepteur couplé protéine G Synthèse chimique Sélectivité 1,2,3-Triazole dérivé Adamantane dérivé Bicyclo[3.1.0]hexane dérivé Bicyclo[3.1.0]hexane-1-carboxamide dérivé Chimie clic Radioligand
- Keyword (en)
- Uronic acid Agonist Organic azide Carboxamide Chlorine Organic compounds Acetylenic compound Adenine derivatives Purine derivatives In vitro Ligand Radiolabelling Nucleoside Structure activity relation A3 adenosine receptor G protein coupled receptor Chemical synthesis Selectivity Click chemistry
- Keyword (es)
- Acido urónico Agonista Azida orgánica Carboxamida Cloro Compuesto orgánico Compuesto acetilénico Adenina derivado Purina derivado In vitro Ligando Marcación radioisotópica Nucleósido Relación estructura actividad Receptor adenosínico A3 Receptor acoplado proteína G Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22367183
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2009.12.018 
https://dx.doi.org/10.1016/j.bmc.2009.12.018
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