2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors
- Author
- GANGJEE, Aleem1 ; JAIN, Hiteshkumar D1 ; PHAN, Jaclyn1 ; XIN GUO1 ; QUEENER, Sherry F2 ; KISLIUK, Roy L3
[1] Division of Medicinal Chemistry, Graduate School of Pharmoceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States
[2] Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
[3] Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, United States - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 2, pp 953-961, 9 p ; ref : 43 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Dihydrofolate reductase Dual inhibitors Furo[2.3-d]pyrimidines Thymidylate synthase
- Keyword (fr)
- Activité biologique Antifolate Antimétabolite Dihydrofolate reductase Escherichia coli Homme In vitro Inhibiteur enzyme Mycobacterium avium Pneumocystis carinii Synthèse chimique Sélectivité Thymidylate synthase Toxoplasma gondii Furo[2,3-d]pyrimidine dérivé Furo[2,3-d]pyrimidine(6-arylsulfanyl-2,4-diamino-5-méthyl) Furopyrimidine Actinomycetes Apicomplexa Bactérie Enterobacteriaceae Enzyme Fungi Imperfecti Fungi Methyltransferases Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa Transferases
- Keyword (en)
- Biological activity Antifolate Antimetabolic Dihydrofolate reductase Escherichia coli Human In vitro Enzyme inhibitor Mycobacterium avium Pneumocystis carinii Chemical synthesis Selectivity Thymidylate synthase Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enterobacteriaceae Enzyme Fungi Imperfecti Fungi Methyltransferases Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa Transferases
- Keyword (es)
- Actividad biológica Antifolato Antimetabólito Dihydrofolate reductase Escherichia coli Hombre In vitro Inhibidor enzima Mycobacterium avium Pneumocystis carinii Síntesis química Selectividad Thymidylate synthase Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enterobacteriaceae Enzima Fungi Imperfecti Fungi Methyltransferases Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22367230
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2009.11.029 
https://dx.doi.org/10.1016/j.bmc.2009.11.029
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