1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity
- Author
- ROMA, Giorgio1 ; DI BRACCIO, Mario1 ; GROSSI, Giancarlo1 ; PIRAS, Daniela1 ; BALLABENI, Vigilio2 ; TOGNOLINI, Massimiliano2 ; BERTONI, Simona2 ; BAROCELLI, Elisabetta2
[1] Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy
[2] Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Università di Parma, Viale G.P. Usberti 27/A, 43100 Parma, Italy - Source
European journal of medicinal chemistry. 2010, Vol 45, Num 1, pp 352-366, 15 p ; ref : 11 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Analgesic Anti-inflammatory Gastric damage Imidazo[1,2-a][1,8]naphthyridines Structure-activity relationships [1,2,4]Triazolo[4,3-a][1,8]naphthyridines
- Keyword (fr)
- Aigu Analgésique Animal Antiinflammatoire Carboxamide Estomac Rat Relation structure activité Souris Synthèse chimique Toxicité Voie orale Gastrotoxicité Imidazo[1,2-a][1,8]naphtyridine dérivé Imidazo[1,2-a][1,8]naphtyridine-6-carboxamide dérivé Imidazonaphtyridine Triazolonaphtyridine [1,2,4]Triazolo[4,3-a][1,8]naphtyridine dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Acute Analgesic Animal Antiinflammatory agent Carboxamide Stomach Rat Structure activity relation Mouse Chemical synthesis Toxicity Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Agudo Analgésico Animal Antiinflamatorio Carboxamida Estómago Rata Relación estructura actividad Ratón Síntesis química Toxicidad Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22375610
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2009.10.020 
https://dx.doi.org/10.1016/j.ejmech.2009.10.020
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arXiv access
