Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket
- Author
- STEWART, Kent D1 ; HUTH, Jeffrey R1 ; SEVERIN, Jean1 ; WALTER, Karl1 ; RICHARDSON, Paul L1 ; BARRETT, Leo W1 ; MEADOWS, Robert1 ; ANDERSON, Steve1 ; KOHLBRENNER, William1 ; MARING, Clarence1 ; KEMPF, Dale J1 ; MOLLA, Akhter1 ; NG, Teresa I1 ; OLEJNICZAK, Edward T2 ; MCDANIEL, Keith1 ; NEWLIN HUTCHINSON, Rebecca1 ; STOLL, Vincent S1 ; MENDOZA, Renaldo R1 ; MATAYOSHI, Edmund D1 ; CARRICK, Robert1 ; MO, Hongmei1
[1] Pharmaceutical Discovery Division, Abbott Laboratories, 100 Abbott Park Rd., R46Y, AP10, Abbott Park, IL 60064-6098, United States
[2] Department of Biochemistry, Vanderbilt University, 804 RRB Nashville, TN 37232, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 2, pp 612-617, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- HIV-1 Structure-activity gp41
- Keyword (fr)
- Antiviral Carboxamide Composé non peptide Conformation Dérivé du biphényle Dérivé du naphtalène Enveloppe virus In vitro Inhibiteur de fusion Mode liaison Produit synthétique Relation structure activité Spectrométrie RMN Triacide carboxylique Virus HIV1 Benzène-1,2,4-tricarboxylique acide(5-[4p-méthoxy-p-biphénylylméthyl 1,2,3,4-tétrahydro-1-naphtyl carbamoyl]) Glycoprotéine gp41 Lentivirus Retroviridae Virus immunodéficience humaine Virus
- Keyword (en)
- Antiviral Carboxamide Non peptide compound Conformation Biphenyl derivatives Naphthalene derivatives Virus envelope In vitro Fusion inhibitor Binding mode Synthetic product Structure activity relation NMR spectrometry Tricarboxylic acid HIV-1 virus Lentivirus Retroviridae Human immunodeficiency virus Virus
- Keyword (es)
- Antiviral Carboxamida Compuesto no péptido Conformación Bifenilo derivado Naftaleno derivado Cubierta virus In vitro Inhibidor fusión Modo de enlace Producto sintético Relación estructura actividad Espectrometría RMN Triácido carboxílico HIV-1 virus Lentivirus Retroviridae Human immunodeficiency virus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22389482
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1016/j.bmcl.2009.11.076 
https://dx.doi.org/10.1016/j.bmcl.2009.11.076
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.bmcl.2009.11.076\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:9:\"\u0000*\u0000jtitle\";s:48:\"Bioorganic & medicinal chemistry letters (Print)\";s:9:\"\u0000*\u0000stitle\";s:32:\"Bioorg. med. chem. lett. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"20\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"617\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0960-894X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"STEWART\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Kent D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:20:{i:0;s:15:\"HUTH, Jeffrey R\";i:1;s:13:\"SEVERIN, Jean\";i:2;s:12:\"WALTER, Karl\";i:3;s:18:\"RICHARDSON, Paul L\";i:4;s:14:\"BARRETT, Leo W\";i:5;s:15:\"MEADOWS, Robert\";i:6;s:15:\"ANDERSON, Steve\";i:7;s:20:\"KOHLBRENNER, William\";i:8;s:16:\"MARING, Clarence\";i:9;s:13:\"KEMPF, Dale J\";i:10;s:13:\"MOLLA, Akhter\";i:11;s:12:\"NG, Teresa I\";i:12;s:20:\"OLEJNICZAK, Edward T\";i:13;s:15:\"MCDANIEL, Keith\";i:14;s:26:\"NEWLIN HUTCHINSON, Rebecca\";i:15;s:16:\"STOLL, Vincent S\";i:16;s:18:\"MENDOZA, Renaldo R\";i:17;s:19:\"MATAYOSHI, Edmund D\";i:18;s:15:\"CARRICK, Robert\";i:19;s:11:\"MO, Hongmei\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.bmcl.2009.11.076\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:9:\"\u0000*\u0000jtitle\";s:48:\"Bioorganic & medicinal chemistry letters (Print)\";s:9:\"\u0000*\u0000stitle\";s:32:\"Bioorg. med. chem. lett. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"20\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"617\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0960-894X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"STEWART\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Kent D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:20:{i:0;s:15:\"HUTH, Jeffrey R\";i:1;s:13:\"SEVERIN, Jean\";i:2;s:12:\"WALTER, Karl\";i:3;s:18:\"RICHARDSON, Paul L\";i:4;s:14:\"BARRETT, Leo W\";i:5;s:15:\"MEADOWS, Robert\";i:6;s:15:\"ANDERSON, Steve\";i:7;s:20:\"KOHLBRENNER, William\";i:8;s:16:\"MARING, Clarence\";i:9;s:13:\"KEMPF, Dale J\";i:10;s:13:\"MOLLA, Akhter\";i:11;s:12:\"NG, Teresa I\";i:12;s:20:\"OLEJNICZAK, Edward T\";i:13;s:15:\"MCDANIEL, Keith\";i:14;s:26:\"NEWLIN HUTCHINSON, Rebecca\";i:15;s:16:\"STOLL, Vincent S\";i:16;s:18:\"MENDOZA, Renaldo R\";i:17;s:19:\"MATAYOSHI, Edmund D\";i:18;s:15:\"CARRICK, Robert\";i:19;s:11:\"MO, Hongmei\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.bmcl.2009.11.076\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.bmcl.2009.11.076\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:9:\"\u0000*\u0000jtitle\";s:48:\"Bioorganic & medicinal chemistry letters (Print)\";s:9:\"\u0000*\u0000stitle\";s:32:\"Bioorg. med. chem. lett. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"20\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"617\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0960-894X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"STEWART\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Kent D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:20:{i:0;s:15:\"HUTH, Jeffrey R\";i:1;s:13:\"SEVERIN, Jean\";i:2;s:12:\"WALTER, Karl\";i:3;s:18:\"RICHARDSON, Paul L\";i:4;s:14:\"BARRETT, Leo W\";i:5;s:15:\"MEADOWS, Robert\";i:6;s:15:\"ANDERSON, Steve\";i:7;s:20:\"KOHLBRENNER, William\";i:8;s:16:\"MARING, Clarence\";i:9;s:13:\"KEMPF, Dale J\";i:10;s:13:\"MOLLA, Akhter\";i:11;s:12:\"NG, Teresa I\";i:12;s:20:\"OLEJNICZAK, Edward T\";i:13;s:15:\"MCDANIEL, Keith\";i:14;s:26:\"NEWLIN HUTCHINSON, Rebecca\";i:15;s:16:\"STOLL, Vincent S\";i:16;s:18:\"MENDOZA, Renaldo R\";i:17;s:19:\"MATAYOSHI, Edmund D\";i:18;s:15:\"CARRICK, Robert\";i:19;s:11:\"MO, Hongmei\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.bmcl.2009.11.076\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:9:\"\u0000*\u0000jtitle\";s:48:\"Bioorganic & medicinal chemistry letters (Print)\";s:9:\"\u0000*\u0000stitle\";s:32:\"Bioorg. med. chem. lett. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"20\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"612\";s:8:\"\u0000*\u0000epage\";s:3:\"617\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0960-894X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"STEWART\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Kent D\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:20:{i:0;s:15:\"HUTH, Jeffrey R\";i:1;s:13:\"SEVERIN, Jean\";i:2;s:12:\"WALTER, Karl\";i:3;s:18:\"RICHARDSON, Paul L\";i:4;s:14:\"BARRETT, Leo W\";i:5;s:15:\"MEADOWS, Robert\";i:6;s:15:\"ANDERSON, Steve\";i:7;s:20:\"KOHLBRENNER, William\";i:8;s:16:\"MARING, Clarence\";i:9;s:13:\"KEMPF, Dale J\";i:10;s:13:\"MOLLA, Akhter\";i:11;s:12:\"NG, Teresa I\";i:12;s:20:\"OLEJNICZAK, Edward T\";i:13;s:15:\"MCDANIEL, Keith\";i:14;s:26:\"NEWLIN HUTCHINSON, Rebecca\";i:15;s:16:\"STOLL, Vincent S\";i:16;s:18:\"MENDOZA, Renaldo R\";i:17;s:19:\"MATAYOSHI, Edmund D\";i:18;s:15:\"CARRICK, Robert\";i:19;s:11:\"MO, Hongmei\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:0:\"\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:77:\"Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
