Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding
- Author
- KUDUK, Scott D1 ; DI MARCO, Christina N1 ; HARTMAN, George D1 ; BILODEAU, Mark T1 ; COFRE, Victoria1 ; PITTS, Daniel R1 ; RAY, William J2 ; LEI MA2 ; WITTMANN, Marion2 ; SEAGER, Matthew2 ; KOEPLINGER, Kenneth3 ; THOMPSON, Chuck D3
[1] Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, United States
[2] Department of Alzheimer's Research, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, United States
[3] Department of Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 2, pp 657-661, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Allosteric modulator Alzheimer's M1 Muscarinic PAM
- Keyword (fr)
- Démence d'Alzheimer Dérivé de la pyridine Dérivé de la quinolone Dérivé de la quinoléine Dérivé du pyrazole Fluor Composé organique In vitro Protéine sérique Relation structure activité Récepteur cholinergique Récepteur muscarinique M1 Régulation allostérique Synthèse chimique Système nerveux central Quinoléine-3-carboxylique acide(5,8-difluoro-1,4-dihydro-4-oxo-1-[5-(1-méthylpyrazol-4-yl)-2-pyridylméthyl])
- Keyword (en)
- Alzheimer disease Pyridine derivatives Quinolone derivatives Quinoline derivatives Pyrazole derivatives Fluorine Organic compounds In vitro Serum protein Structure activity relation Cholinergic receptor M1 Muscarinic receptor Allosteric regulation Chemical synthesis Central nervous system
- Keyword (es)
- Demencia Alzheimer Piridina derivado Quinolone derivado Quinolina derivado Pirazol derivado Fluor Compuesto orgánico In vitro Proteína sérica Relación estructura actividad Receptor colinérgico Receptor muscarínico M1 Regulación alostérica Síntesis química Sistema nervioso central
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22389492
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.11.059 
https://dx.doi.org/10.1016/j.bmcl.2009.11.059
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