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2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells

Author
ZHENG, Chun-Lei1 ; CHE, Xiao-Fang2 ; AKIYAMA, Shin-Ichi2 ; MIYAZAWA, Keisuke3 ; TOMODA, Akio3
[1] Department of Medical Oncology, Cancer Hospital, Fudan University, 270 Dong An Road, 200032, Shanghai, China
[2] Department of Molecular Oncology, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
[3] Department of Biochemistry, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo 160-8402, Japan
Source

International journal of oncology. 2010, Vol 36, Num 3, pp 641-650, 10 p ; ref : 36 ref

ISSN
1019-6439
Scientific domain
Medical oncology
Publisher
Editorial Academy of the International Journal of Oncology, Athens
Publication country
Greece
Document type
Article
Language
English
Author keyword
2-aminophenoxazine-3-one A549 cells NF-κB intracellular pH reactive oxygen species
Keyword (fr)
Acidification Adénocarcinome bronchopulmonaire Apoptose Cancer du poumon Cancérologie Espèces réactives de l'oxygène Facteur transcription NFκB Homme Intracellulaire Mort cellulaire Stress oxydatif pH Lignée A549 Cancer Pathologie de l'appareil respiratoire Pathologie des bronches Pathologie des poumons Tumeur maligne
Keyword (en)
Acidification Bronchopulmonary adenocarcinoma Apoptosis Lung cancer Cancerology Reactive oxygen species Transcription factor NFκB Human Intracellular Cell death Oxidative stress pH Cancer Respiratory disease Bronchus disease Lung disease Malignant tumor
Keyword (es)
Acidificación Adenocarcinoma bronchopulmonar Apoptosis Cáncer del pulmón Cancerología Especies reactivas del oxígeno Factor transcripción NFκB Hombre Intracelular Muerte celular Estrés oxidativo pH Cáncer Aparato respiratorio patología Bronquio patología Pulmón patología Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11A Tumors of the respiratory system and mediastinum

Discipline
Pulmonology Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22396663

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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