2,2'-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced Peripheral blood mononuclear cells
- Author
- RUPESH, K. R1 ; MOUSHUMI PRIYA, A1 ; SUNDARAKRISHNAN, B1 ; VENKATESAN, R2 ; LAKSHMI, B. S3 ; JAYACHANDRAN, S1
[1] Department of Biotechnology, School of Life Sciences, Pondicherry University, Pondicherry, India
[2] Department of Chemistry, Pondicherry University, Pondicherry, India
[3] Centre for Biotechnology, Anna University, Chennai, India - Source
European journal of medicinal chemistry. 2010, Vol 45, Num 6, pp 2141-2146, 6 p ; ref : 34 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Copper complexes Cyclooxegenase-2 Inducible nitric oxide synthase Mitogen activated protein kinases PBMCs
- Keyword (fr)
- Activité biologique Antiinflammatoire Base Schiff Bipyridyle Complexe dinucléaire Cuivre Complexe Cytokine Dérivé de la pyridine Facteur nécrose tumorale α Imine In vitro Interleukine 1β Liquide biologique Mitogen-activated protein kinase Mononucléaire Mécanisme action Nitric-oxide synthase Régulation Sang 1,10-Phénanthroline-5,6-dione Enzyme Métal transition Complexe Oxidoreductases Transferases
- Keyword (en)
- Biological activity Antiinflammatory agent Schiff base Bipyridines Dinuclear complex Copper Complexes Cytokine Pyridine derivatives Tumor necrosis factor α Imine In vitro Interleukin 1β Biological fluid Mitogen-activated protein kinase Mononuclear cell Mechanism of action Nitric-oxide synthase Regulation(control) Blood Enzyme Transition metal Complexes Oxidoreductases Transferases
- Keyword (es)
- Actividad biológica Antiinflamatorio Base Schiff Complejo dinuclear Cobre Complejo Citoquina Piridina derivado Factor necrosis tumoral α Imina In vitro Interleuquina 1β Líquido biológico Mitogen-activated protein kinase Mononuclear Mecanismo acción Nitric-oxide synthase Regulación Sangre Enzima Metal transición Complejo Oxidoreductases Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22701827
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2010.01.041 
https://dx.doi.org/10.1016/j.ejmech.2010.01.041
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