2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics
- Author
- QINGPING ZENG1 ; BOURBEAU, Matthew P1 ; CHUN LI3 ; TOMINEY, Elizabeth3 ; XIN HUANG4 ; HOFFMAN, Douglas5 ; YAMANE, Harvey6 ; TASKER, Andrew S1 ; DOMINGUEZ, Celia1 ; VISWANADHAN, Vellarkad N1 ; HUNGATE, Randall1 ; XIAOLING ZHANG2 ; WOHLHIETER, G. Erich1 ; GUOMIN YAO1 ; MONENSCHEIN, Holger1 ; RIDER, James T1 ; LEE, Matthew R1 ; SHIWEN ZHANG2 ; LOFGREN, Julie2 ; FREEMAN, Daniel2
[1] Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[2] Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[3] Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[4] Chemistry Research and Discovery, Amgen, Inc., 1 Kendall Square, Cambridge, MA 02139, United States
[5] Small Molecule Process and Product Development, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States
[6] Protein Science, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 5, pp 1652-1656, 5 p ; ref : 26 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Akt protein kinase Animal Dérivé de l'isoquinoléine Dérivé du thiadiazole Fluor Composé organique Glioblastome Homme In vitro In vivo Inhibiteur Isozyme Lignée cellulaire Non-specific serine/threonine protein kinase Pharmacocinétique Rat Relation structure activité Souris Synthèse chimique Sélectivité Transduction signal Tumeur maligne Voie intraveineuse 1,3,4-Thiadiazole dérivé 1,3,4-Thiadiazole(2-[2-amino-3-(4-[trifluorométhyl]phényl)propylamino]-5-[6-isoquinolyl]) Lignée U87MG Cancer Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Akt protein kinase Animal Isoquinoline derivatives Thiadiazole derivatives Fluorine Organic compounds Glioblastoma Human In vitro In vivo Inhibitor Isozyme Cell line Non-specific serine/threonine protein kinase Pharmacokinetics Rat Structure activity relation Mouse Chemical synthesis Selectivity Signal transduction Malignant tumor Intravenous administration Cancer Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Akt protein kinase Animal Isoquinoleína Tiadiazol derivado Fluor Compuesto orgánico Glioblastoma Hombre In vitro In vivo Inhibidor Isozima Línea celular Non-specific serine/threonine protein kinase Farmacocinética Rata Relación estructura actividad Ratón Síntesis química Selectividad Transducción señal Tumor maligno Vía intravenosa Cáncer Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22824764
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.01.046 
https://dx.doi.org/10.1016/j.bmcl.2010.01.046
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