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3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3β

Author
ARNOST, Michael1 ; PIERCE, Al1 ; TER HAAR, Ernst1 ; LAUFFER, David1 ; MADDEN, Jaren1 ; TANNER, Kirk1 ; GREEN, Jeremy1
[1] Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, United States
Source

Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 5, pp 1661-1664, 4 p ; ref : 26 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
Binding efficiency GSK3β Hit-to-lead Kinase inhibitors Lead-like Ligand efficiency Pyrazolones
Keyword (fr)
Activité biologique Diffraction RX Dérivé de la pyridine Dérivé du pyrazole Hydrazone Inhibiteur Ligand Modèle moléculaire Modélisation Structure cristalline Structure moléculaire Synthèse chimique Tau-protein kinase EC 2-7-11-26 Pyrazole-3,4-dione(5-[4-méthoxyphényl])-3-[3-méthoxyphényl]hydrazone Pyrazole-3,4-dione(5-[4-méthoxyphényl])-3-[3-pyridyl]hydrazone Pyrazole-3,4-dione(5-[4-méthoxyphényl])-3-phénylhydrazone Pyrazolone dérivé Enzyme Transferases
Keyword (en)
Biological activity X ray diffraction Pyridine derivatives Pyrazole derivatives Hydrazone Inhibitor Ligand Molecular model Modeling Crystalline structure Molecular structure Chemical synthesis Tau-protein kinase Enzyme Transferases
Keyword (es)
Actividad biológica Difracción RX Piridina derivado Pirazol derivado Hidrazona Inhibidor Ligando Modelo molecular Modelización Estructura cristalina Estructura molecular Síntesis química Tau-protein kinase Enzima Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B11 Miscellaneous

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F09 Miscellaneous

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
22824766

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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