2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
- Author
- GERSPACHER, Marc1 ; FURET, Pascal1 ; CHENE, Patrick1 ; DE POVER, Alain1 ; HOFMANN, Francesco1 ; BAFFERT, Fabienne1 ; BUHL, Thomas1 ; AICHHOLZ, Reiner1 ; BLASCO, Francesca1 ; ENDRES, Ralf1 ; TRAPPE, Jörg1 ; DRUECKES, Peter1 ; PISSOT-SOLDERMANN, Carole1 ; GAUL, Christoph1 ; HOLZER, Philipp1 ; VANGREVELINGHE, Eric1 ; LANG, Marc1 ; ERDMANN, Dirk1 ; RADIMERSKI, Thomas1 ; REGNIER, Catherine H1
[1] Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 5, pp 1724-1727, 4 p ; ref : 7 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- JAK3 JAK1 JAK2 inhibitor JAK2 Janus kinase Kinase inhibitors Tyk2
- Keyword (fr)
- Animal Biodisponibilité Carboxamide Dérivé de la benzamide Dérivé du benzooxazole In vitro Inhibiteur Pharmacocinétique Rat Relation structure activité Synthèse chimique Sélectivité Transduction signal Transferases Voie orale Benzamide(N,2-diméthyl-4-[benzooxazol-2-ylamino]) Non-specific protein-tyrosine kinase Enzyme Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Bioavailability Carboxamide Benzamide derivatives Benzoxazole derivatives In vitro Inhibitor Pharmacokinetics Rat Structure activity relation Chemical synthesis Selectivity Signal transduction Transferases Oral administration Non-specific protein-tyrosine kinase Enzyme Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Biodisponibilidad Carboxamida Benzamida derivado In vitro Inhibidor Farmacocinética Rata Relación estructura actividad Síntesis química Selectividad Transducción señal Transferases Vía oral Enzima Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22824781
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.01.069 
https://dx.doi.org/10.1016/j.bmcl.2010.01.069
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