2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent
- Author
- HONDA, Tadashi1 ; PADEGIMAS, Eric M1 ; DAVID, Emilie1 ; SUNDARARAJAN, Chitra1 ; LIBY, Karen T2 ; WILLIAMS, Charlotte2 ; SPORN, Michael B2 ; VISNICK, Melean3
[1] Department of Chemistry, Dartmouth College, Hanover, NH 03755, United States
[2] Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, United States
[3] Reata Pharmaceutical Inc., Dallas, TX 75063, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 7, pp 2275-2278, 4 p ; ref : 11 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Acid anhydride Inducers of heme oxygenase-1 Inhibitors of nitric oxide production Oleanolic acid Triterpene
- Keyword (fr)
- Activité biologique Activité enzymatique Anhydride organique Animal Antiinflammatoire Cytoprotecteur Distribution Dérivé de l'oléanane Heme oxygenase (decyclizing) In vitro In vivo Inhibiteur Lignée cellulaire Monocyte Monoxyde d'azote Nitrile Pharmacocinétique Souris Synthèse chimique Terpénoïde Tissu Triterpène Voie intrapéritonéale Biodistribution Bis(2-cyano-3,10-dioxooléana-1,9(11)-dién-28-oïque) anhydride Lignée RAW264 7 Enzyme Mammalia Oxidoreductases Rodentia Vertebrata
- Keyword (en)
- Biological activity Enzymatic activity Organic anhydride Animal Antiinflammatory agent Cytoprotector Distribution Oleanane derivatives Heme oxygenase (decyclizing) In vitro In vivo Inhibitor Cell line Monocyte Nitric oxide Nitrile Pharmacokinetics Mouse Chemical synthesis Terpenoid Tissue Triterpene Intraperitoneal administration Enzyme Mammalia Oxidoreductases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Actividad enzimática Anhídrido orgánico Animal Antiinflamatorio Citoprotector Distribución Oleanano derivado Heme oxygenase (decyclizing) In vitro In vivo Inhibidor Línea celular Monocito Nitrógeno monóxido Nitrilo Farmacocinética Ratón Síntesis química Terpenoide Tejido Triterpeno Vía intraperitoneal Enzima Mammalia Oxidoreductases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22824897
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.02.007 
https://dx.doi.org/10.1016/j.bmcl.2010.02.007
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