Pyridinyl aminohydantoins as small molecule BACE1 inhibitors
- Author
- PING ZHOU1 ; YANFANG LI1 ; TURNER, M. James2 ; BARD, Jonathan2 ; MALAMAS, Michael S1 ; ROBICHAUD, Albert J1 ; YI FAN1 ; ZHENG WANG1 ; CHOPRA, Rajiv3 ; OLLAND, Andrea3 ; YUN HU2 ; MAGOLDA, Ronald L1 ; PANGALOS, Menelas2 ; REINHART, Peter H2
[1] Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, United States
[2] Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543-8000, United States
[3] Department of Chemical Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 7, pp 2326-2329, 4 p ; ref : 12 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Alzheimer's disease BACE1 Pyridinyl aminohydantoins β-Secretase
- Keyword (fr)
- Antialzheimer Aspartic endopeptidases Complexe enzyme inhibiteur Cycle 5 chaînons Cycle 6 chaînons Dérivé de la pyridine Dérivé du benzène Hétérocycle azote Inhibiteur enzyme Modèle moléculaire Modélisation Molécule petite Protéine précurseur amyloïde Relation structure activité Synthèse chimique Imidazol-5-one(2-amino-4-[2,5-difluorophényl]-1-méthyl-4-[4-pyridyl]) Inhibiteur BACE1 Memapsin 2 Enzyme Fluor Composé organique Hydrolases Peptidases
- Keyword (en)
- Antialzheimer agent Aspartic endopeptidases Inhibitor enzyme complex Five membered ring Six membered ring Pyridine derivatives Benzene derivatives Nitrogen heterocycle Enzyme inhibitor Molecular model Modeling Small molecule Amyloid precursor protein Structure activity relation Chemical synthesis Memapsin 2 Enzyme Fluorine Organic compounds Hydrolases Peptidases
- Keyword (es)
- Antialzheimer Aspartic endopeptidases Complejo enzima inhibidor Ciclo 5 eslabones Ciclo 6 eslabones Piridina derivado Benceno derivado Heterociclo nitrógeno Inhibidor enzima Modelo molecular Modelización Molécula pequeña Proteína precursor amiloide Relación estructura actividad Síntesis química Enzima Fluor Compuesto orgánico Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22824909
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.01.136 
https://dx.doi.org/10.1016/j.bmcl.2010.01.136
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