Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization
- Author
- CUMMING, Jared1 ; BABU, Suresh2 ; LE, Thuy2 ; GUOQING LI1 ; MCHUGH, Nansie1 ; ORTH, Peter1 ; OZGUR, Lynne2 ; PARKER, Eric1 ; SAIONZ, Kurt2 ; STAMFORD, Andrew1 ; STRICKLAND, Corey1 ; TADESSE, Dawit2 ; YING HUANG1 ; VOIGT, Johannes1 ; LILI ZHANG1 ; QI ZHANG1 ; CARROL, Carolyn2 ; XIA CHEN1 ; FAVREAU, Leonard1 ; GREENLEE, William1 ; TAO GUO2 ; KENNEDY, Matthew1 ; KUVELKAR, Reshma1
[1] Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States
[2] Ligand Pharmaceuticals, Inc., 3000 Eastpark Boulevard, Cranbury, NJ 08512, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2837-2842, 6 p ; ref : 25 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Alzheimer's disease Aspartyl protease inhibitors BACE Peptidomimetics β-Secretase
- Keyword (fr)
- Aminoalcool Aminoéther Animal Antialzheimer Aspartic endopeptidases Carboxamide Composé non peptide Composé peptidomimétique Dérivé de la pipérazine Dérivé de la pyrrolidine Dérivé du benzène In vitro In vivo Inhibiteur enzyme Protéine précurseur amyloïde Relation structure activité Souris Sulfonamide Synthèse chimique Voie souscutanée β-secretase Inhibiteur BACE1 Isophtalamide dérivé Memapsin 2 Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Aminoalcohol Aminoether Animal Antialzheimer agent Aspartic endopeptidases Carboxamide Non peptide compound Peptidomimetic compound Piperazine derivatives Pyrrolidine derivatives Benzene derivatives In vitro In vivo Enzyme inhibitor Amyloid precursor protein Structure activity relation Mouse Sulfonamide Chemical synthesis Subcutaneous administration β-secretase Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Aminoalcohol Aminoeter Animal Antialzheimer Aspartic endopeptidases Carboxamida Compuesto no péptido Compuesto peptidomimético Piperazina derivado Benceno derivado In vitro In vivo Inhibidor enzima Proteína precursor amiloide Relación estructura actividad Ratón Sulfonamida Síntesis química Vía subcutánea β-secretase Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22825016
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.03.050 
https://dx.doi.org/10.1016/j.bmcl.2010.03.050
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