Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia
- Author
- YINFA YAN1 ; PING ZHOU1 ; CARRICK, Tikva3 ; MARQUIS, Karen L3 ; PAUSCH, Mark H3 ; ROBICHAUD, Albert J1 ; ROTELLA, David P1 ; FEENSTRA, Rolf2 ; KRUSE, Chris G2 ; REINDERS, Jan-Hendrik2 ; VAN DER NEUT, Martina2 ; LAI, Margaret3 ; ZHANG, Jean3 ; KOWAL, Dianne M3
[1] Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, United States
[2] Solvay Pharmaceuticals Research Laboratories, C.J. van Houtenlaan 36, 1381 CP, Weesp, Netherlands
[3] Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2983-2986, 4 p ; ref : 13 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Dopamine D2 partial agonist Schizophrenia Serotonin reuptake inhibitor
- Keyword (fr)
- Agoniste partiel Antipsychotique Brome Composé organique Composé aromatique Composé bicyclique Dérivé de la quinolone Dérivé de la quinoléine Ether Hétérocycle azote In vitro Inhibiteur recapture Lactame Neurotransmetteur Psychotrope Relation structure activité Récepteur dopaminergique D2 Sulfonamide Synthèse chimique Sérotonine 3-Azabicyclo[3.2.1]octane dérivé 8-Azabicyclo[3.2.1]octane dérivé Quinoléin-2-one dérivé
- Keyword (en)
- Partial agonist Antipsychotic Bromine Organic compounds Aromatic compound Bicyclic compound Quinolone derivatives Quinoline derivatives Ether Nitrogen heterocycle In vitro Reuptake inhibitor Lactam Neurotransmitter Psychotropic Structure activity relation D2 Dopamine receptor Sulfonamide Chemical synthesis Serotonin
- Keyword (es)
- Agonista parcial Antipsicótico Bromo Compuesto orgánico Compuesto aromático Compuesto bicíclico Quinolone derivado Quinolina derivado Eter Heterociclo nitrógeno In vitro Inhibidor recaptura Lactamo Neurotransmisor Psicotropo Relación estructura actividad Receptor dopaminérgico D2 Sulfonamida Síntesis química Serotonina
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B03 Psycholeptics: tranquillizer, neuroleptic.
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E03 Psycholeptics: tranquillizer, neuroleptic…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22825049
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.02.105 
https://dx.doi.org/10.1016/j.bmcl.2010.02.105
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