Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors
- Author
- NEVES, Gilda1 2 3 ; MENEGATTI, Ricardo4 5 ; ANTONIO, Camila B1 ; GRAZZIOTTIN, Luiza R1 ; VIEIRA, Renan O3 ; RATES, Stela M. K1 ; NOËL, François3 ; BARREIRO, Eliezer J5 ; FRAGA, Carlos A. M5
[1] Laboratório de Psicofarmacologia Experimental, Faculdade de Farmácia, Universidade Federal do Rio Grande do sul, Porto Alegre, Brazil
[2] Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
[3] Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
[4] Faculdade de Farmácia, Universidade Federal do Goiás, Goiânia, Brazil
[5] Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, PO Box 68.023, 21941-902 Rio de Janeiro, RJ, Brazil - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 5, pp 1925-1935, 11 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 1-Aryl-1,2,3-triazole 1-Arylpyrazole Atypical antipsychotic drugs Imidazo[1,2-a]pyridine N-Phenylpiperazine derivatives Schizophrenia
- Keyword (fr)
- Activité biologique Animal Antipsychotique atypique Chlore Composé organique Dérivé de l'imidazopyridine Dérivé de la pipérazine Dérivé du pyrazole Fluor Composé organique Ligand Psychotrope Récepteur dopaminergique D2 Récepteur sérotoninergique 5-HT1A Schizophrénie Souris Synthèse chimique Voie orale 1,2,3-Triazole dérivé Imidazo[1,2-a]pyridine dérivé Pipérazine(1-[1-(4-chlorophényl)pyrazol-4-ylméthyl]-4-phényl) Pipérazine(1-[1-(4-fluorophényl)pyrazol-4-ylméthyl]-4-phényl) Mammalia Psychose Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Atypical antipsychotic Chlorine Organic compounds Imidazopyridine derivatives Piperazine derivatives Pyrazole derivatives Fluorine Organic compounds Ligand Psychotropic D2 Dopamine receptor 5-HT1A Serotonine receptor Schizophrenia Mouse Chemical synthesis Oral administration Mammalia Psychosis Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Antipsicótico atípico Cloro Compuesto orgánico Imidazopiridina derivado Piperazina derivado Pirazol derivado Fluor Compuesto orgánico Ligando Psicotropo Receptor dopaminérgico D2 Receptor serotoninérgico 5-HT1A Esquizofrenia Ratón Síntesis química Vía oral Mammalia Psicosis Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B03 Psycholeptics: tranquillizer, neuroleptic.
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E03 Psycholeptics: tranquillizer, neuroleptic…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22830555
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.01.040 
https://dx.doi.org/10.1016/j.bmc.2010.01.040
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