11β-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches
- Author
- ROLLINGER, Judith M1 ; KRATSCHMAR, Denise V2 ; SCHUSTER, Daniela3 ; PFISTERER, Petra H1 ; GUMY, Christel2 ; AUBRY, Evelyne M2 ; BRANDSTÖTTER, Sarah1 ; STUPPNER, Hermann1 ; WOLBER, Gerhard3 ; ODERMATT, Alex2
[1] Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria
[2] Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
[3] Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 4, pp 1507-1515, 9 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 11β-HSD1 Diabetes Eriobotrya japonica Glucocorticoid receptor Metabolic syndrome
- Keyword (fr)
- 11β-Hydroxysteroid dehydrogenase Criblage virtuel Diabète Dérivé de l'ursane Embryon Feuille végétal Homme In vitro Inhibition Isolement Isozyme Lignée cellulaire Lysat Origine végétale Pharmacognosie Plante médicinale Rein Relation structure activité Rosaceae Récepteur glucocorticoïde Récepteur hormonal Syndrome métabolique Corosolique acide Eriobotrya japonica Lignée HEK293 Ursolique acide(11-oxo) Ursolique acide(3-acétyl-11-oxo) Angiospermae Dicotyledones Enzyme Oxidoreductases Spermatophyta
- Keyword (en)
- 11β-Hydroxysteroid dehydrogenase Virtual screening Diabetes mellitus Ursane derivatives Embryo Plant leaf Human In vitro Inhibition Isolation Isozyme Cell line Lysate Plant origin Pharmacognosy Medicinal plant Kidney Structure activity relation Rosaceae Glucocorticoid receptor Hormonal receptor Metabolic syndrome Angiospermae Dicotyledones Enzyme Oxidoreductases Spermatophyta
- Keyword (es)
- 11β-Hydroxysteroid dehydrogenase Cribado virtual Diabetes Ursano derivado Embrión Hoja vegetal Hombre In vitro Inhibición Aislamiento Isozima Línea celular Lisado Origen vegetal Farmacognosia Planta medicinal Riñón Relación estructura actividad Rosaceae Receptor glucocorticoide Receptor hormonal Síndrome metabólico Angiospermae Dicotyledones Enzima Oxidoreductases Spermatophyta
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22830585
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.01.010 
https://dx.doi.org/10.1016/j.bmc.2010.01.010
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