2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity
- Author
- XIAOYI ZHANG1 ; WEI WANG2 ; SHENLING CHENG1 ; MING ZHAO1 ; MEIQING ZHENG1 ; HENG WEI CHANG2 ; JIANHUI WU1 ; SHIQI PENG1
[1] College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
[2] C S Bio Company, 20 Kelly Court, Menlo Park, CA 94025, United States - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 4, pp 1536-1554, 19 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 3D QSAR Anti-thrombotic Conformation Modification Tetrahydroisoquinoline
- Keyword (fr)
- Animal Anticoagulant Antithrombotique Carboxamide Conformation Dérivé de l'isoquinoléine In vitro In vivo Inhibiteur thromboagrégation Modèle 3 dimensions Modèle moléculaire Modélisation Prédiction Rat Relation dose réponse Relation structure activité Synthèse chimique Sélectivité Voie intraveineuse Voie orale α-Aminoacide Isoquinoléine-3-carboxamide(2-[2-aminoacyl]-N-[1-carboxyalkyl]) QSAR Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Anticoagulant Antithrombotic agent Carboxamide Conformation Isoquinoline derivatives In vitro In vivo Antiplatelet agent Three dimensional model Molecular model Modeling Prediction Rat Dose activity relation Structure activity relation Chemical synthesis Selectivity Intravenous administration Oral administration α-Aminoacid Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Anticoagulante antitrombōtico Carboxamida Conformación Isoquinoleína In vitro In vivo Inhibidor tromboagregación Modelo 3 dimensiones Modelo molecular Modelización Predicción Rata Relación dosis respuesta Relación estructura actividad Síntesis química Selectividad Vía intravenosa Vía oral α-Aminoácido Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22830588
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.01.009 
https://dx.doi.org/10.1016/j.bmc.2010.01.009
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