3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies
- Author
- ASADA, Masaki1 ; IWAHASHI, Maki1 ; YOSHIKAWA, Ken1 ; SATO, Kazutoyo1 ; NARITA, Masami1 ; OHUCHIDA, Shuichi1 ; NAKAI, Hisao1 ; TODA, Masaaki1 ; OBITSU, Tetsuo1 ; KINOSHITA, Atsushi1 ; NAKAI, Yoshihiko1 ; ONODA, Takahiro2 ; NAGASE, Toshihiko1 ; TANAKA, Motoyuki1 ; YAMAURA, Yoshiyuki1 ; TAKIZAWA, Hiroya1
[1] Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan
[2] Fukui Research Institute, Ono Pharmaceutical Co., Ltd, Technoport, Yamagishi, Mikuni, Sakai, Fukui 913-8538, Japan - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 4, pp 1641-1658, 18 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Antagonist EP3 receptor Uterine contraction
- Keyword (fr)
- Activité biologique Animal Antagoniste Carboxamide Chaîne latérale Contraction musculaire Dérivé de l'acide arylpropionique Fluor Composé organique In vitro In vivo Optimisation Pharmacocinétique Rat Récepteur prostanoïde EP3 Synthèse chimique Sélectivité Utérus Voie orale Benzènepropionique acide(4-[2,5-difluorophénoxyméthyl]-2-[1-(3,5-diméthylphényl)-3-méthylbutylcarbamoyl]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Antagonist Carboxamide Side chain Muscle contraction Arylpropionic acid derivatives Fluorine Organic compounds In vitro In vivo Optimization Pharmacokinetics Rat EP3 prostanoid receptor Chemical synthesis Selectivity Uterus Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Antagonista Carboxamida Cadena lateral Contracción muscular Arilpropionico ácido derivado Fluor Compuesto orgánico In vitro In vivo Optimización Farmacocinética Rata Receptor prostanoide EP3 Síntesis química Selectividad Utero Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02P Genital system. Reproduction
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22830599
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2009.12.068 
https://dx.doi.org/10.1016/j.bmc.2009.12.068
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