Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol
- Author
- BONIFAZI, Evelyn L1 ; RIOS-LUCI, Carla2 3 ; LEON, Leticia G2 3 ; BURTON, Gerardo1 ; PADRON, José M2 3 ; MISICO, Rosana I1
[1] Departamento de Química Orgánica and UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina
[2] Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain
[3] BioLab, Instituto Canario de Investigación del Cáncer (ICIC), C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 7, pp 2621-2630, 10 p ; ref : 34 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Antiproliferative Lapachol Lapachone Naphthoquinone
- Keyword (fr)
- Activité biologique Anticancéreux Cellule tumorale Col utérus Côlon Dérivé de la naphtoquinone Glande mammaire Homme In vitro Lapachol Lignée cellulaire Lipophilie Poumon Propriété physicochimique Quinone Synthèse chimique Tumeur solide 1,4-Naphtoquinone(2,5-dihydroxy-3-isoprényl) Naphto[2,3-b]furane dérivé Naphto[2,3-b]furane-4,9-dione(2,3-dihydro-5-hydroxy-2-[1-méthylvinyl]) Naphtofurane Cancer Tumeur maligne
- Keyword (en)
- Biological activity Antineoplastic agent Tumor cell Uterine cervix Colon Naphthoquinone derivatives Mammary gland Human In vitro Cell line Lipophilicity Lung Physicochemical properties Quinone Chemical synthesis Solid tumor Cancer Malignant tumor
- Keyword (es)
- Actividad biológica Anticanceroso Célula tumoral Cuello útero Colón Glándula mamaria Hombre In vitro Línea celular Lipofilia Pulmón Propiedad fisicoquímica Quinona Síntesis química Tumor sólido Cáncer Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22831006
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.02.032 
https://dx.doi.org/10.1016/j.bmc.2010.02.032
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