Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling

Author

ELO, Laura L^{1 2} ; MYKKÄNEN, Juha¹ ; KNIP, Mikael^{10 9} ; SIMELL, Olli³ ; LAHESMAA, Riitta^{1 11} ; NIKULA, Tuomas¹ ; JÄRVENPÄÄ, Henna¹ ; SIMELL, Satu³ ; AITTOKALLIO, Tero^{1 2} ; HYÖTY, Heikki^{5 6} ; ILONEN, Jorma^{4 7} ; VEIJOLA, Riitta⁸ ; SIMELL, Tuula³
[1] Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 20521 Turku, Finland
[2] Department of Mathematics, University of Turku, 20014 Turku, Finland
[3] Department of Pediatrics, University of Turku, 20014 Turku, Finland
[4] Immunogenetics Laboratory, University of Turku, 20014 Turku, Finland
[5] Department of Virology, University of Tampere, 33014 Tampere, Finland
[6] Centre for Laboratory Medicine, University Hospital of Tampere, 33520 Tampere, Finland
[7] Department of Clinical Microbiology, University of Kuopio, 70211 Kuopio, Finland
[8] Department of Pediatrics, University of Oulu, 90014 Oulu, Finland
[9] Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, 00014 Helsinki, Finland
[10] Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland
[11] Immune Disease Institute, Harvard Medical School, Boston, MA, United States

Source

Journal of autoimmunity (Print). 2010, Vol 35, Num 1, pp 70-76, 7 p ; ref : 56 ref

ISSN

0896-8411

Scientific domain

Immunology, immunopathology, allergology

Publisher

Elsevier, Kidlington

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

Autoantibodies Differential gene expression Longitudinal data Molecular networks Pathway analysis Prediabetes Type 1 diabetes

Keyword (fr)

Anticorps Autoanticorps Autoimmunité Diabète de type 1 Enfant Expression génique Génome Immunologie Précoce Réponse immune Réseau Suppression Profil d'expression génique Endocrinopathie Homme Immunopathologie Maladie autoimmune

Keyword (en)

Antibody Autoantibody Autoimmunity Type 1 diabetes Child Gene expression Genome Immunology Early Immune response Network Suppression Gene expression profile Endocrinopathy Human Immunopathology Autoimmune disease

Keyword (es)

Anticuerpo Autoanticuerpo Autoinmunidad Diabetes de tipo 1 Niño Expresión genética Genoma Inmunología Precoz Respuesta inmune Red Supresión Perfil de expresión genética Endocrinopatía Hombre Inmunopatología Enfermedad autoinmune

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A06 Fundamental immunology

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance

Discipline

Endocrinopathies Fundamental immunology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

22858085

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS