3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents

Author

SHAW, Arthur Y^{1 5} ; LIAU, Hao-Han¹ ; LU, Pei-Jung² ; YANG, Chia-Ning³ ; LEE, Chien-Hsing² ; CHEN, Jun-Yan⁴ ; ZHIGANG XU⁵ ; FLYNN, Gary⁵
[1] Department of Chemistry, Tamkang University, Taipei 251, Taiwan, Province of China
[2] Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, Province of China
[3] Institute of Biotechnology, National University of Kaohsiung, Kaohsiung 700, Taiwan, Province of China
[4] Department of Life Science, National University of Kaohsiung, Kaohsiung 700, Taiwan, Province of China
[5] Department of pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85724, United States

Source

Bioorganic & medicinal chemistry. 2010, Vol 18, Num 9, pp 3270-3278, 9 p ; ref : 15 ref

ISSN

0968-0896

Scientific domain

Biochemistry, molecular biology, biophysics; Pharmacology drugs

Publisher

Elsevier, Amsterdam

Publication country

Netherlands

Document type

Article

Language

English

Author keyword

3,5-Diaryl-1H-pyrazole Apoptosis-inducing agent Mitochondrial apoptotic pathway Molecular scaffold Structure-activity relationship

Keyword (fr)

Anticancéreux Apoptose Carcinome non petite cellule Cellule tumorale Cytotoxicité Côlon Dérivé du benzène Dérivé du biphényle Dérivé du pyrazole Estomac Homme In vitro Lignée cellulaire Mitochondrie Modèle moléculaire Modélisation Mécanisme action Ovaire Poumon Prédiction Relation structure activité Synthèse chimique LIgnée OVCA Lignée AGS Lignée H460 Lignée SW620 Pyrazole(3-biphényl-2-yl-5-[4-méthoxyphényl]) QSAR

Keyword (en)

Antineoplastic agent Apoptosis Non small cell carcinoma Tumor cell Cytotoxicity Colon Benzene derivatives Biphenyl derivatives Pyrazole derivatives Stomach Human In vitro Cell line Mitochondria Molecular model Modeling Mechanism of action Ovary Lung Prediction Structure activity relation Chemical synthesis

Keyword (es)

Anticanceroso Apoptosis Carcinoma no pequeña célula Célula tumoral Citotoxicidad Colón Benceno derivado Bifenilo derivado Pirazol derivado Estómago Hombre In vitro Línea celular Mitocondria Modelo molecular Modelización Mecanismo acción Ovario Pulmón Predicción Relación estructura actividad Síntesis química

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline

Pharmacological treatments

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

22891300

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS