1-2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
- Author
- TOLLEFSON, Michael B1 ; ACKER, Brad A1 ; JACOBSEN, E. J1 ; HUGHES, Robert O1 ; WALKER, John K1 ; FOX, David N. A2 ; PALMER, Michael J2 ; FREEMAN, Sandra K1 ; YING YU1 ; BOND, Brian R1
[1] Pfizer Global Research and Development, 700 Chesterfield Parkway, Chesterfield, MO 63017, United States
[2] Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 10, pp 3125-3128, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Phosphodiesterase 5 inhibitors
- Keyword (fr)
- 3',5'-Cyclic-GMP phosphodiesterase Animal Antihypertenseur Appareil circulatoire Canal ionique Chien Chimiothérapie Composé bicyclique Cycle 6 chaînons Dérivé de la pipérazine Dérivé de la pyridine Dérivé de la pyrimidine Halogénoéther Hypertension artérielle Hétérocycle azote In vitro In vivo Inhibiteur de la phosphodiestérase 5 Inhibiteur enzyme Isozyme Pathologie expérimentale Pharmacocinétique Pyrazolopyrimidine dérivé Rat Relation structure activité Synthèse chimique Toxicité Voie intraveineuse Voie orale Canal hERG Canal potassium Cardiotoxicité Pyrazolo[4,3-d]pyrimidine dérivé Carnivora Enzyme Esterases Fissipedia Fluor Composé organique Hydrolases Mammalia Pathologie de l'appareil circulatoire Phosphoric diester hydrolases Rodentia Traitement Vertebrata
- Keyword (en)
- 3',5'-Cyclic-GMP phosphodiesterase Animal Antihypertensive agent Circulatory system Ionic channel Dog Chemotherapy Bicyclic compound Six membered ring Piperazine derivatives Pyridine derivatives Pyrimidine derivatives Haloether Hypertension Nitrogen heterocycle In vitro In vivo Phosphodiesterase 5 inhibitor Enzyme inhibitor Isozyme Experimental disease Pharmacokinetics Pyrazolopyrimidine derivatives Rat Structure activity relation Chemical synthesis Toxicity Intravenous administration Oral administration Carnivora Enzyme Esterases Fissipedia Fluorine Organic compounds Hydrolases Mammalia Cardiovascular disease Phosphoric diester hydrolases Rodentia Treatment Vertebrata
- Keyword (es)
- 3',5'-Cyclic-GMP phosphodiesterase Animal Antihipertensivo Aparato circulatorio Canal iónico Perro Quimioterapia Compuesto bicíclico Ciclo 6 eslabones Piperazina derivado Piridina derivado Pirimidina derivado Haloéter Hipertensión arterial Heterociclo nitrógeno In vitro In vivo Inhibidor fosfodiesterasa 5 Inhibidor enzima Isozima Patología experimental Farmacocinética Pyrazolopirimidina derivado Rata Relación estructura actividad Síntesis química Toxicidad Vía intravenosa Vía oral Carnivora Enzima Esterases Fissipedia Fluor Compuesto orgánico Hydrolases Mammalia Aparato circulatorio patología Phosphoric diester hydrolases Rodentia Tratamiento Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F05 Antihypertensive agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22896319
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.03.106 
https://dx.doi.org/10.1016/j.bmcl.2010.03.106
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