2' Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR
- Author
- BUDZIK, Brian1 ; GARZYA, Vincenzo1 ; DONGCHUAN SHI1 ; FOLEY, James J1 ; RIVERO, Ralph A1 ; LANGMEAD, Christopher J1 ; WATSON, Jeannette1 ; ZINING WU1 ; FORBES, Ian T1 ; JIAN JIN1
[1] Discovery Research and Centers of Excellence for Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 12, pp 3540-3544, 5 p ; ref : 25 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2' Biaryl amides Novel M1 agonists Subtype selective M1 muscarinic acetylcholine receptor agonist
- Keyword (fr)
- Agoniste Amide Carboxamide Chlore Composé organique Dérivé de la pipéridine Dérivé du biphényle Fluor Composé organique In vitro Relation structure activité Récepteur cholinergique Récepteur muscarinique M1 Synthèse chimique Sélectivité Biphényle-2-carboxamide(5p-chloro-2p-fluoro-N-[4-pipéridylméthyl])
- Keyword (en)
- Agonist Amides Carboxamide Chlorine Organic compounds Piperidine derivatives Biphenyl derivatives Fluorine Organic compounds In vitro Structure activity relation Cholinergic receptor M1 Muscarinic receptor Chemical synthesis Selectivity
- Keyword (es)
- Agonista Carboxamida Cloro Compuesto orgánico Piperidina derivado Bifenilo derivado Fluor Compuesto orgánico In vitro Relación estructura actividad Receptor colinérgico Receptor muscarínico M1 Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22902428
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.04.128 
https://dx.doi.org/10.1016/j.bmcl.2010.04.128
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