(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
- Author
- YEH, Teng-Kuang1 ; TSAI, Ting-Yueh1 ; HUANG, Chung-Yu1 ; YEH, Kai-Chia1 ; HUANG, Yu-Lin1 ; HUANG, Chih-Hsiang1 ; HUANG, Yu-Wen1 ; WANG, Min-Hsien1 ; TANG, Hung-Kuan1 ; CHAO, Yu-Sheng1 ; CHEN, Chiung-Tong1 ; JIAANG, Weir-Torn1 ; HSU, Tsu1 ; CHENG, Jai-Hong1 ; XIN CHEN1 ; SONG, Jen-Shin1 ; SHY, Horng-Shing1 ; CHIOU, Mei-Chun1 ; CHIEN, Chia-Hui1 ; TSENG, Ya-Ju1
[1] Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli Country 350, Taiwan, Province of China - Source
Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 12, pp 3596-3600, 5 p ; ref : 23 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Dipeptidyl peptidase IV Inhibitor
- Keyword (fr)
- Activité biologique Animal Biodisponibilité Dipeptide Dipeptidyl-peptidase IV Dérivé de la pyrrolidine Fluor Composé organique Inhibiteur Longue durée Nitrile Peptide Pharmacocinétique Rat Souris Synthèse chimique Sélectivité Voie orale Pyrrolidine-2-carbonitrile(1-[1,1-diméthyl-2-(pyrrolidine-1-carbonyl)éthylglycyl]-4-fluoro) Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Bioavailability Dipeptides Dipeptidyl-peptidase IV Pyrrolidine derivatives Fluorine Organic compounds Inhibitor Long lasting Nitrile Peptides Pharmacokinetics Rat Mouse Chemical synthesis Selectivity Oral administration Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Biodisponibilidad Dipéptido Dipeptidyl-peptidase IV Fluor Compuesto orgánico Inhibidor Larga duración Nitrilo Péptido Farmacocinética Rata Ratón Síntesis química Selectividad Vía oral Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22902440
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2010.04.124 
https://dx.doi.org/10.1016/j.bmcl.2010.04.124
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arXiv access
