Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation
- Author
- OGBURN, Evan T1 ; JONES, David R1 ; MASTERS, Andrea R1 ; CONG XU1 ; YINGYING GUO2 ; DESTA, Zeruesenay1
[1] Indiana University School of Medicine, Indianapolis, Indiana, India
[2] Drug Disposition Laboratories and Business Operations, Lilly Research Laboratories, Indianapolis, Indiana, India - Source
Drug metabolism and disposition. 2010, Vol 38, Num 7, pp 1218-1229, 12 p ; ref : 3/4 p
- CODEN
- DMDSAI
- ISSN
- 0090-9556
- Scientific domain
- Pharmacology drugs
- Publisher
- American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antirétroviral Antiviral Efavirenz Hydroxylation Identification In vitro Métabolisme secondaire Primaire Voie métabolique Cytochrome P450 2A6 Composé acétylénique Composé non nucléoside Dérivé de la benzoxazine Enzyme Inhibiteur allostérique Inhibiteur enzyme Inhibiteur reverse transcriptase Nucleotidyltransferases RNA-directed DNA polymerase Transferases
- Keyword (en)
- Antiretroviral agent Antiviral Efavirenz Hydroxylation Identification In vitro Secondary metabolism Primary Metabolic pathway Acetylenic compound Non nucleoside compound Benzoxazine derivatives Enzyme Allosteric inhibitor Enzyme inhibitor Reverse transcriptase inhibitor Nucleotidyltransferases RNA-directed DNA polymerase Transferases
- Keyword (es)
- Antiretroviral Antiviral Efavirenz Hidroxilación Identificación In vitro Metabolismo secundario Primario Vía métabolica Compuesto acetilénico Compuesto no nucleósido Benzoxazina derivado Enzima Inhibidor alostérico Inhibidor enzima Inhibitor reverse transcriptase Nucleotidyltransferases RNA-directed DNA polymerase Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22973291
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1124/dmd.109.031393 
https://dx.doi.org/10.1124/dmd.109.031393
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