Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression
- Author
- OVERSTREET, David H1 ; NAIMOLI, V. M2 ; GRIEBEL, Guy2
[1] Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7178, United States
[2] Department of Psychopharmacology, Sanofi-Aventis, 92220 Bagneux, France - Source
Pharmacology, biochemistry and behavior. 2010, Vol 96, Num 2, pp 206-210, 5 p ; ref : 3/4 p
- CODEN
- PBBHAU
- ISSN
- 0091-3057
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs; Psychology, psychopathology, psychiatry
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Desipramine FSL model of depression Forced swim test Saredutant Social interaction test
- Keyword (fr)
- Antagoniste Antidépresseur Désipramine Etat dépressif Interaction sociale Modèle animal Psychotrope Récepteur tachykinine NK2 Sarédutant Dérivé de la dihydrodibenzazépine Test nage forcée Catécholamine Composé tricyclique Inhibiteur recapture Neurotransmetteur Noradrénaline Récepteur tachykinine Trouble de l'humeur
- Keyword (en)
- Antagonist Antidepressant agent Desipramine Depression Social interaction Animal model Psychotropic NK2 Tachykinin receptor Saredutant Catecholamine Tricyclic compound Reuptake inhibitor Neurotransmitter Norepinephrine Tachykinin receptor Mood disorder
- Keyword (es)
- Antagonista Antidepresor Desipramina Estado depresivo Interacción social Modelo animal Psicotropo Receptor taquikinina NK2 Saredutant Catecolamina Compuesto tricíclico Inhibidor recaptura Neurotransmisor Noradrenalina Receptor taquikinina Trastorno humor
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C07 Mood disorders / 002B18C07A Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03G Mood disorders / 770-D03G01 Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 22983773
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.pbb.2010.05.006 
https://dx.doi.org/10.1016/j.pbb.2010.05.006
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